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SYVN1 modulates papillary thyroid carcinoma progression by destabilizing HMGB1
Fei Duan1, Fanli Kong2, Taifeng Jiang2
1Department of Otolaryngology Head and Neck Surgery, The Second Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, 330006, China.
Cell Division
|April 28, 2024
Summary
The E3 ubiquitin ligase synoviolin (SYVN1) suppresses papillary thyroid cancer (PTC) growth by targeting HMGB1 for degradation. This finding highlights SYVN1 as a potential therapeutic target for PTC.
Area of Science:
- Oncology
- Molecular Biology
- Biochemistry
Background:
- E3 ubiquitin ligase synoviolin (SYVN1) is implicated in various human cancers.
- Understanding SYVN1's specific roles in papillary thyroid cancer (PTC) is crucial for developing targeted therapies.
Purpose of the Study:
- To investigate the functions and molecular mechanisms of SYVN1 in papillary thyroid cancer (PTC).
- To evaluate SYVN1 as a potential therapeutic target for PTC.
Main Methods:
- Utilized gain- and loss-of-function experiments in PTC cell lines (NPA87, TPC-1).
- Performed cellular function and molecular biology investigations.
- Analyzed SYVN1's interaction with HMGB1, including ubiquitination and degradation.
- Assessed SYVN1's impact on tumor xenografts in mouse models.
Main Results:
- Overexpression of SYVN1 significantly inhibited PTC cell proliferation, migration, and invasion.
- SYVN1 was found to interact with and promote the ubiquitination and degradation of HMGB1.
- SYVN1 suppressed tumor xenograft formation in vivo.
- Overexpression of HMGB1 partially reversed the inhibitory effects of SYVN1.
Conclusions:
- SYVN1 inhibits PTC cell proliferation, migration, and invasion, potentially by degrading HMGB1.
- SYVN1 represents a promising therapeutic target for papillary thyroid cancer.
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