Long-Noncoding-RNA HOTAIR Upregulation is Associated with Poor Breast Cancer Outcome: A Systematic Review and Meta Analysis
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View abstract on PubMed
Summary
This summary is machine-generated.High expression of the long non-coding RNA HOTAIR (HOX transcript antisense RNA) is linked to poorer survival outcomes in breast cancer patients. This finding suggests HOTAIR could serve as a valuable prognostic marker for breast cancer prognosis.
Area Of Science
- Oncology
- Molecular Biology
- Genetics
Background
- Breast cancer is a leading cause of cancer death in women globally, with a pronounced impact in developing nations.
- Improved prognostic and recurrence markers are crucial for refining breast cancer clinical management.
- Long non-coding RNA HOTAIR (HOX transcript antisense RNA) has emerged as a potential prognostic indicator associated with adverse outcomes.
Purpose Of The Study
- To systematically evaluate the association between long non-coding RNA HOTAIR expression and survival rates in breast cancer patients.
- To synthesize evidence from existing studies through a meta-analysis to determine the prognostic value of HOTAIR.
Main Methods
- A comprehensive literature search was conducted across major scientific databases (PubMed, Scopus, Google Scholar, etc.).
- Keywords included "long non-coding RNA," "lncRNA," "HOTAIR," "breast cancer," "prognosis," and "survival."
- Meta-analysis of seven studies involving 533 patients was performed to assess the relationship between HOTAIR expression and survival outcomes, using STATA v.17.
Main Results
- High HOTAIR expression was significantly associated with poorer overall survival (pooled HR: 1.69) and disease-free survival (pooled HR: 2.40).
- Elevated HOTAIR levels correlated with reduced distant metastatic-free survival (HR: 1.75) and were linked to ductal carcinoma type (pooled OR: 3.27).
- While associated with positive lymph node infiltration (pooled OR: 2.38), this did not reach statistical significance (p=0.26).
Conclusions
- Upregulation of lncRNA HOTAIR is a significant indicator of worse disease-free survival and distant metastatic-free survival in breast cancer.
- HOTAIR holds potential as a prognostic biomarker for identifying breast cancer patients with a higher risk of recurrence and metastasis.
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