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Experimental and clinical intestinal transplantation
Scandinavian Journal of Gastroenterology. Supplement
|January 1, 1985
Summary
Small intestinal transplantation survival in dogs significantly improved with cyclosporine, extending mean survival to 103 days. This immunosuppressant offers new hope for treating intestinal failure.
Area of Science:
- Transplantation immunology
- Gastroenterology
- Surgical innovation
Background:
- Small intestinal transplantation is crucial for treating intestinal failure.
- Previous attempts had limited success due to rejection and graft-versus-host disease.
- Cyclosporine shows promise in mitigating these complications.
Purpose of the Study:
- To evaluate the efficacy of cyclosporine in prolonging survival after total small intestinal allotransplantation in dogs.
- To establish a method for histological monitoring of allograft rejection.
Main Methods:
- Total small intestinal allotransplantation was performed in dogs.
- Parenteral cyclosporine was administered as an immunosuppressant.
- Histological monitoring of exteriorized allograft pouches was developed.
Main Results:
- Cyclosporine treatment extended mean survival to 103 days, compared to 12 days in untreated dogs.
- Two dogs survived over 200 days, and one lived over 400 days.
- Histological monitoring correlated with rejection events.
Conclusions:
- Parenteral cyclosporine significantly improves survival in canine small intestinal allotransplantation.
- Cyclosporine effectively combats both rejection and graft-versus-host disease.
- Histological monitoring provides a valuable tool for assessing allograft status.