Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

  1. Home
  3. Research Domains
  5. Biomedical And Clinical Sciences
  7. Oncology And Carcinogenesis
  9. Predictive And Prognostic Markers
  11. Prognostic Role Of Platelet-to-lymphocyte Ratio And Neutrophil-to-lymphocyte Ratio In Patients With Non-metastatic And Metastatic Prostate Cancer: A Meta-analysis And Systematic Review

Prognostic role of platelet-to-lymphocyte ratio and neutrophil-to-lymphocyte ratio in patients with non-metastatic and metastatic prostate cancer: A meta-analysis and systematic review

Stefano Salciccia1, Marco Frisenda1, Giulio Bevilacqua1

  • 1Department of Urology, Sapienza Rome University, Policlinico Umberto I, 00161 Rome, Italy.

Asian Journal of Urology
|April 29, 2024

Related Experiment Videos

Neutrophil Isolation and Analysis to Determine their Role in Lymphoma Cell Sensitivity to Therapeutic Agents
14:04

Neutrophil Isolation and Analysis to Determine their Role in Lymphoma Cell Sensitivity to Therapeutic Agents

Published on: March 25, 2016

15.3K
Author Spotlight: Investigating Immune Cell Dynamics in the Tumor Microenvironment — Challenges and Innovations in Cancer Prognosis
07:32

Author Spotlight: Investigating Immune Cell Dynamics in the Tumor Microenvironment — Challenges and Innovations in Cancer Prognosis

Published on: April 12, 2024

1.3K
Microarray-based Identification of Individual HERV Loci Expression: Application to Biomarker Discovery in Prostate Cancer
13:19

Microarray-based Identification of Individual HERV Loci Expression: Application to Biomarker Discovery in Prostate Cancer

Published on: November 2, 2013

16.6K

View abstract on PubMed

Summary
This summary is machine-generated.

The neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) show prognostic value in prostate cancer (PCa). High NLR is linked to increased mortality risk in metastatic PCa patients receiving systemic treatment.

Area of Science:

  • Oncology
  • Inflammation Biomarkers
  • Prognostic Indicators

Background:

  • The neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) are emerging biomarkers.
  • Their prognostic significance in prostate cancer (PCa) requires comprehensive analysis.

Purpose of the Study:

  • To systematically evaluate the prognostic value of NLR and PLR in PCa patients.
  • To stratify analyses based on disease status: non-metastatic versus metastatic.

Main Methods:

  • A meta-analysis was conducted following PRISMA guidelines.
  • Pooled event rates and hazard ratios were calculated using random-effects models.
  • Data were synthesized from 42 selected articles.

Main Results:

Keywords:
Meta-analysisMetastaticNeutrophil-to-lymphocyte ratioPlatelet-to-lymphocyte ratio

Related Experiment Videos

Neutrophil Isolation and Analysis to Determine their Role in Lymphoma Cell Sensitivity to Therapeutic Agents
14:04

Neutrophil Isolation and Analysis to Determine their Role in Lymphoma Cell Sensitivity to Therapeutic Agents

Published on: March 25, 2016

15.3K
Author Spotlight: Investigating Immune Cell Dynamics in the Tumor Microenvironment — Challenges and Innovations in Cancer Prognosis
07:32

Author Spotlight: Investigating Immune Cell Dynamics in the Tumor Microenvironment — Challenges and Innovations in Cancer Prognosis

Published on: April 12, 2024

1.3K
Microarray-based Identification of Individual HERV Loci Expression: Application to Biomarker Discovery in Prostate Cancer
13:19

Microarray-based Identification of Individual HERV Loci Expression: Application to Biomarker Discovery in Prostate Cancer

Published on: November 2, 2013

16.6K
  • The platelet-to-lymphocyte ratio (PLR) showed a significant association with non-organ confined PCa (pooled risk difference: 0.30).
  • In non-metastatic PCa, both NLR and PLR indicated increased mortality risk (HR: 1.33 and 1.47, respectively), though not statistically significant.
  • In metastatic PCa, a high NLR significantly correlated with increased overall mortality risk (HR: 1.79).

    • Conclusions:

    • NLR and PLR reflect inflammatory and immune status in PCa patients.
    • A high NLR demonstrates a significant predictive value for overall mortality in metastatic PCa patients undergoing systemic therapy.
    • Heterogeneity among studies highlights the need for further research.
    Prostatic neoplasm
    Radical prostatectomy