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Recommencement of atezolizumab with associated pulmonary sarcoid-like reaction
Khai Tam1, Michael Wallace1, Siobhain Mulrennan1
1Respiratory and Hepatology Department Sir Charles Gairdner Hospital Perth Western Australia Australia.
Abstract:
An 81 year old male with Child-Pugh A cirrhosis and metastatic hepatocellular carcinoma (HCC) treated with 3-weekly atezolizumab and bevacizumab developed a pulmonary sarcoid-like reaction (SLR) after 5 months. Atezolizumab, an immune checkpoint inhibitor, was identified as the likely culprit. He was treated with prednisolone, resulting in improvement, and was successfully rechallenged with both atezolizumab and bevacizumab.
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