Median Effective Dose of Ciprofol Combined With Sufentanil for Inhibiting the Upper Gastrointestinal Endoscopic...

Area of Science:

• Anesthesiology
• Geriatric Medicine
• Pharmacology

Background:

• Ciprofol is a novel sedative anesthetic.
• Optimal ciprofol dosage in elderly patients remains undetermined.
• Sufentanil is a common clinical opioid.

Purpose of the Study:

• Determine the median effective dose (ED50) of ciprofol combined with sufentanil for anesthesia in elderly patients undergoing gastrointestinal endoscopy.
• Establish the 95% confidence interval (95% CI) for the ED50.
• Compare ciprofol dosage requirements between different age groups of elderly patients.

Main Methods:

• A study involving 57 patients undergoing upper gastrointestinal endoscopy.
• Patients were divided into two groups: 65-74 years (Group A) and over 75 years (Group B).
• The modified Dixon sequential method was used to determine the ED50 of ciprofol, with a fixed dose of sufentanil (0.1 μg/kg) administered prior to ciprofol.

Main Results:

• The ED50 of ciprofol combined with sufentanil was 0.23 mg/kg (95% CI: 0.09–0.30 mg/kg) in Group A (65-74 years).
• The ED50 of ciprofol combined with sufentanil was 0.18 mg/kg (95% CI: 0.13–0.22 mg/kg) in Group B (over 75 years).
• Vital signs and adverse events were monitored throughout the perioperative period.

Conclusions:

• The ED50 of ciprofol when co-administered with sufentanil for upper gastrointestinal endoscopy differs between elderly patient age groups.
• Elderly patients aged 65-74 years required a higher ED50 of ciprofol (0.23 mg/kg) compared to those over 75 years (0.18 mg/kg).
• These findings provide crucial data for optimizing ciprofol and sufentanil dosage in geriatric anesthesia.