Contemporary trends in the incidence and timing of spinal metastases: A population-based study
- Husain Shakil 1,2,3, Armaan K Malhotra 1,2,3, Jetan H Badhiwala 1, Vishwathsen Karthikeyan 1, Ahmad Essa 4,3, Yingshi He 3, Michael G Fehlings 1,5, Arjun Sahgal 6, Nicolas Dea 7, Alex Kiss 2,8, Christopher D Witiw 1,2,3, Donald A Redelmeier 2,8,9, Jefferson R Wilson 1,2,3
- Husain Shakil 1,2,3, Armaan K Malhotra 1,2,3, Jetan H Badhiwala 1
- 1Division of Neurosurgery, Department of Surgery, University of Toronto, Toronto, Ontario, Canada.
- 2Institute of Health Policy Management and Evaluation, University of Toronto, Toronto, Ontario, Canada.
- 3Li Ka Shing Knowledge Institute, St. Michael's Hospital, Toronto, Ontario, Canada.
- 4Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
- 5Krembil Research Institute, Toronto Western Hospital, Toronto, Ontario, Canada.
- 6Department of Radiation Oncology, Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada.
- 7Neurosurgical and Orthopedic Spine Program, Vancouver General Hospital, University of British Columbia, Vancouver, British Columbia, Canada.
- 8ICES, Toronto, Ontario, Canada.
- 9Department of Medicine, Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada.
- 0Division of Neurosurgery, Department of Surgery, University of Toronto, Toronto, Ontario, Canada.
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View abstract on PubMed
Summary
This summary is machine-generated.The incidence of spinal metastases is rising, especially in older adults. Trends and timing differ significantly by primary cancer type, highlighting the need for specialized care.
Area Of Science
- Oncology
- Public Health
- Epidemiology
Background
- Spinal metastases are a serious complication in advanced cancer patients.
- Understanding temporal trends and patient demographics is crucial for managing this condition.
Purpose Of The Study
- To analyze temporal trends in spinal metastasis incidence and timing.
- To examine patient demographics and primary cancer associations.
- To identify at-risk populations and inform subspecialty care needs.
Main Methods
- Population-based retrospective cohort study in Ontario, Canada (2007-2019).
- Analysis of health data for 37,375 patients with spine metastases.
- Primary outcomes: annual incidence and time to metastasis after primary diagnosis.
Main Results
- Age-standardized incidence increased by 2.2% annually, with the largest rise in patients aged ≥85 years (5.2%).
- Lung cancer showed the highest annual incidence and risk (10.3% at 10 years), while prostate cancer had the greatest increase in incidence (6.5%).
- Gastrointestinal cancer patients had the lowest risk (1.0% at 10 years).
Conclusions
- Spinal metastasis incidence is increasing, particularly in older populations.
- Significant variations exist in incidence and timing across different primary cancer types.
- Findings underscore the growing need for specialized care for patients with spinal metastases.
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