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Related Experiment Video

Updated: Jun 27, 2025

Application of CRISPR Interference CRISPRi for Gene Silencing in Pathogenic Species of Leptospira
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AMR mechanisms in L. interrogans serovars: a comprehensive study.

Pavlo Petakh1,2, Oleksandr Kamyshnyi2

  • 1Department of Biochemistry and Pharmacology, Uzhhorod National University, Uzhhorod, Ukraine.

Frontiers in Cellular and Infection Microbiology
|April 29, 2024
PubMed
Summary

Antimicrobial resistance (AMR) in Leptospira interrogans is a growing concern. Our study identified 32 AMR genes, including unique efflux pumps in serovar Pomona, highlighting serovar-specific resistance mechanisms.

Keywords:
Leptospira interrogansantibioticleptospiral serovarsleptospirosisresistance

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Area of Science:

  • Microbiology
  • Genomics
  • Public Health

Background:

  • Antimicrobial resistance (AMR) poses a significant global health threat.
  • Limited data exists on AMR mechanisms in Leptospira interrogans, the bacteria causing leptospirosis.

Purpose of the Study:

  • To identify antimicrobial resistance genes in Leptospira interrogans.
  • To explore serovar-specific AMR mechanisms.

Main Methods:

  • Whole-genome sequencing (WGS) of 98 Leptospira strains from 10 serovars.
  • Utilized the PATRIC tool (BV-BRC) for AMR gene identification.

Main Results:

  • Identified 32 AMR-associated genes, with 20 consistently found across strains.
  • Discovered unique efflux pump systems in the Pomona serovar, suggesting distinct resistance strategies.

Conclusions:

  • Uncovered common and serovar-specific AMR genetic elements in Leptospira.
  • The unique efflux pumps in serovar Pomona offer new insights into resistance.
  • Findings emphasize the need for targeted interventions and interdisciplinary collaboration to combat leptospirosis and AMR.