Related Experiment Video
Updated: Jun 27, 2025

04:46
Rat Model of Adhesive Capsulitis of the Shoulder
Published on: September 28, 2018
7.4K
Adhesive Capsulitis Following Improper Tetanus-Diphtheria (Td) Booster Administration
David Weinberg1, Mackinzie McDaniel1, Jason Pan1
1Physical Medicine and Rehabilitation, University of Pennsylvania, Philadelphia, USA.
Cureus
|April 29, 2024
Summary
Adhesive capsulitis, a rare shoulder complication, can occur after improper vaccine injection into the deltoid muscle. This case highlights a potential link between tetanus-diphtheria (Td) vaccination errors and this debilitating condition.
Area of Science:
- Orthopedics
- Immunology
- Sports Medicine
Background:
- Adhesive capsulitis is a shoulder condition characterized by stiffness and pain.
- Shoulder Injury Related to Vaccine Administration (SIRVA) encompasses various shoulder pathologies resulting from incorrect vaccine injection.
- Improper intramuscular deltoid vaccine administration can lead to needle placement errors, affecting joint structures.
Observation:
- A previously healthy middle-aged female developed left shoulder pain and stiffness after a tetanus-diphtheria (Td) booster vaccination.
- The patient reported the injection was administered higher than usual in the deltoid muscle.
- Symptoms progressed over two weeks, leading to significant loss of shoulder range of motion.
Findings:
- The patient was diagnosed with adhesive capsulitis four months after symptom onset.
- This represents the first reported case of adhesive capsulitis following an improper tetanus-diphtheria (Td) vaccine administration.
- The patient was referred for physical therapy but was lost to follow-up, leaving recovery status uncertain.
Implications:
- This case suggests a potential association between incorrect vaccine administration technique and the development of adhesive capsulitis.
- Further research is needed to understand the temporal course and recovery patterns of vaccine-induced adhesive capsulitis compared to classic adhesive capsulitis.
- Clinicians should be aware of SIRVA as a differential diagnosis in patients presenting with shoulder pain and stiffness post-vaccination.
Related Concept Videos
Vaccinations
44.4K
Overview
44.4K
Myasthenia Gravis: Overview and Treatment
1.4K
Myasthenia gravis is a neuromuscular transmission disorder characterized by weakness and increased fatigability of skeletal muscles. It is an autoimmune disease affecting approximately one in 2000 people, where antibodies against the α1 subunit of nicotinic acetylcholine receptors are produced.
These antibodies interfere with the function of the nicotinic receptors in three ways: by binding to the receptor and disrupting acetylcholine binding; by causing cross-linking of receptors which...
These antibodies interfere with the function of the nicotinic receptors in three ways: by binding to the receptor and disrupting acetylcholine binding; by causing cross-linking of receptors which...
1.4K
Immunological Memory
602
Immunological memory, a pivotal pillar of the adaptive immune system, is responsible for the body's ability to remember and respond more swiftly and effectively to previously encountered pathogens. This remarkable feature is what makes vaccines so effective in preventing diseases.
What is Immunological Memory?
Immunological memory is an integral function of the immune system that allows it to recognize and react more rapidly and effectively to pathogens previously encountered. This feature...
What is Immunological Memory?
Immunological memory is an integral function of the immune system that allows it to recognize and react more rapidly and effectively to pathogens previously encountered. This feature...
602
Directly Acting Muscle Relaxants: Dantrolene and Botulinum Toxin
674
Directly acting muscle relaxants like dantrolene and botulinum toxin (BoNT) have distinct mechanisms and applications. Dantrolene, a hydantoin derivative, acts on the ryanodine receptor (RYR1) in skeletal muscle cells. RYR1 are calcium channels present at the sarcoplasmic reticulum membrane. In response to excitation, they release calcium ions from the sarcoplasmic reticulum to the cytosol. Calcium promotes actin-myosin-mediated contraction of muscles.
The binding of dantrolene to the RYR1...
The binding of dantrolene to the RYR1...
674
Skeletal Muscle Relaxants: Adverse Effects
361
Skeletal muscle relaxants are widely used for muscle paralysis and relieving pain following any muscle injury or stiffness. However, depending on the drug type, they can have adverse effects that range from mild to severe. Usually, nondepolarizing neuromuscular blockers have minimal side effects. For example, drugs like d-tubocurarine, cisatracurium, and rocuronium cause hypotension, whereas drugs like baclofen, when stopped abruptly, can lead to the recurrence of spastic conditions.
Unlike...
Unlike...
361
Myasthenia Gravis: Diagnostic Tests
800
Myasthenia gravis is an autoimmune condition affecting neuromuscular transmission, causing generalized weakness in skeletal muscles. Initial diagnoses rely on patients' signs, symptoms, and medical history. The challenge lies in distinguishing myasthenia from other muscular dystrophies. An important diagnostic feature is the significant improvement of symptoms after administering anticholinesterase inhibitors.
The edrophonium test is a diagnostic tool for myasthenia gravis. It involves...
The edrophonium test is a diagnostic tool for myasthenia gravis. It involves...
800

