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Updated: Jun 27, 2025

Robotic Myotomy and Partial Fundoplication for Achalasia
Published on: August 11, 2023
Complex Antiplatelet Therapy Management in Patients Requiring Urgent Interventions for Pseudoachalasia and Esophageal
Charles Vallejo1, Kushinga Bvute1, Oscar L Hernandez1
1Internal Medicine, Florida Atlantic University, Boca Raton, USA.
Insights
Intravenous cangrelor provided effective antiplatelet bridging therapy for a patient unable to take oral medications after coronary stenting. This approach successfully prevented stent thrombosis during a necessary endoscopic procedure.
Area of Science:
- Cardiology
- Gastroenterology
- Pharmacology
Background:
- Coronary artery disease (CAD) and esophageal strictures pose complex management challenges.
- Percutaneous coronary intervention (PCI) requires antiplatelet therapy, often with oral agents like clopidogrel.
- Esophageal obstructions can prevent oral medication intake, necessitating alternative strategies.
Abstract:
This case report describes the use of intravenous (IV) cangrelor as a transient tool for antiplatelet bridging therapy in a 70-year-old male with coronary artery disease and esophageal strictures who underwent recent percutaneous coronary intervention (PCI) and subsequently required a pre-oral endoscopic myomectomy (POEM) procedure. The patient was switched from oral clopidogrel to IV cangrelor drip prior to the procedure, which was successful in preventing stent thrombosis. The case highlights the potential benefits of IV antiplatelet therapy in patients unable to tolerate oral medications in the setting of esophageal obstructions following recent coronary stent placement in a critical care setting.
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