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The Chemokine CXCL7 is Correlated with LDH-A and Predicts the Prognosis of Patients with Colorectal Cancer

  • 0Department of Pharmacy, Bozhou Hospital of Anhui Medical University, 236800 Bozhou, Anhui, China.
Frontiers in Bioscience (landmark Edition) +

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April 29, 2024

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April 29, 2024

View abstract on PubMed

Summary

This summary is machine-generated.

Chemokine (C-X-C) ligand 7 (CXCL7) expression correlates with glycolysis and is a significant prognostic factor in colorectal cancer (CRC). High CXCL7 levels indicate a poorer overall survival for CRC patients.

Area Of Science

  • Oncology
  • Molecular Biology
  • Biochemistry

Background

  • Colorectal cancer (CRC) is a major global health concern.
  • Glycolysis plays a role in cancer progression.
  • Chemokine (C-X-C) ligand 7 (CXCL7) is a potential biomarker.

Purpose Of The Study

  • To investigate the relationship between CXCL7 expression and glycolysis in CRC.
  • To determine the prognostic value of CXCL7 in CRC patients.

Main Methods

  • Immunohistochemistry was used to assess CXCL7 and lactate dehydrogenase A (LDH-A) expression in 158 CRC tissue samples.
  • Patients were stratified into high and low expression groups.
  • Correlation analysis and survival analysis were performed.

Main Results

  • CXCL7 and LDH-A expression were elevated in CRC tissues compared to non-CRC tissues.
  • Higher expression correlated with advanced N stage and TNM stage.
  • CXCL7 expression showed a strong positive correlation with LDH-A expression.
  • High CXCL7 expression was identified as an independent predictor of poor overall survival.

Conclusions

  • Increased CXCL7 expression is linked to enhanced glycolysis (indicated by LDH-A) in CRC.
  • CXCL7 serves as a significant independent prognostic biomarker for colorectal cancer.

Keywords: