Related Experiment Videos
[Computer-assisted in vivo study of capillary permeability]
Wiener Medizinische Wochenschrift. Supplement
|January 1, 1985
Summary
Capillary permeability (KPU) assessed via nailfold capillaroscopy and sodium fluorescein (Na-flu) revealed significant microvascular changes in functional and organic microangiopathies. Therapeutic interventions showed variable effects on capillary leakage and interstitial dispersion.
Area of Science:
- Vascular Biology
- Microcirculation Research
- Diagnostic Imaging Techniques
Context:
- Capillaroscopy is a non-invasive in vivo method for studying terminal circulation.
- Assessing capillary permeability (KPU) and microvascular function is crucial for understanding various vascular diseases.
Purpose:
- To systematically investigate capillary permeability (KPU) in the nailfold using sodium fluorescein (Na-flu).
- To evaluate KPU and Na-flu distribution in healthy individuals and patients with microangiopathies.
- To study the effects of therapeutic measures on microcirculation parameters.
Summary:
- Dynamic capillaroscopy and video-densitometry quantified transcapillary passage and interstitial distribution of Na-flu.
- Increased pericapillary fluorescence and juxtacapillary halo diameter were observed in functional and organic microangiopathies.
- Systemic fibrinolysis and intra-arterial PGE1 significantly increased capillary leakage, while other therapies showed varied effects.
Impact:
- Establishes objective criteria for diagnosing microangiopathies based on KPU and Na-flu dynamics.
- Provides insights into the efficacy of different therapeutic strategies for microvascular disorders.
- Highlights the utility of capillaroscopy in evaluating microcirculatory dysfunction and treatment response.