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Mechanosensing by Piezo1 and its implications in the kidney
Xi Yuan1,2, Xiaoduo Zhao3, Weidong Wang2,4
1Department of Physiology, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, China.
Acta Physiologica (Oxford, England)
|April 29, 2024
Summary
Piezo1 channels are crucial mechanosensitive proteins in mammals. This review highlights their role in kidney function and disease, suggesting Piezo1 as a potential therapeutic target for renal conditions.
Area of Science:
- Molecular Biology
- Physiology
- Biophysics
Background:
- Piezo1 is a vital mechanosensitive ion channel in mammals.
- It converts mechanical stimuli into cellular signals, influencing diverse physiological processes.
- Growing evidence implicates Piezo1 in kidney function and disease.
Purpose of the Study:
- To review the structure, properties, and modulation of Piezo1.
- To focus on Piezo1's distribution and role in renal physiology and pathology.
- To identify potential therapeutic targets for kidney diseases involving Piezo1.
Main Methods:
- Literature review of Piezo1 structure and function.
- Analysis of Piezo1's role in renal cell biology.
- Examination of Piezo1's involvement in kidney diseases.
Main Results:
- Piezo1's unique structure enables mechanotransduction.
- Piezo1 activity is modulated by various factors.
- Piezo1 is significantly expressed in the kidney and impacts its function.
- Dysregulation of Piezo1 is linked to renal pathologies.
Conclusions:
- Piezo1 is a key player in kidney physiology and disease.
- Understanding Piezo1's role offers insights into novel therapeutic strategies for renal disorders.
- Targeting Piezo1 may hold promise for treating kidney diseases.
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