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A Current Perspective on Delayed Puberty and Its Management
1Dokuz Eylül University Faculty of Medicine, Department of Pediatric Endocrinology, İzmir, Turkey
Journal of Clinical Research in Pediatric Endocrinology
|April 29, 2024
Summary
Delayed puberty, often due to hypogonadism, requires understanding its types and treatments. This review explores traditional and new physiological induction therapies for improved fertility outcomes.
Area of Science:
- Endocrinology
- Pediatrics
- Reproductive Medicine
Background:
- Delayed puberty is the absence of secondary sex characteristics development during childhood.
- Hypogonadism, a common cause, presents as hypergonadotropic or hypogonadotropic forms.
- Constitutional delay of growth and puberty (CDGP) is the most frequent cause of hypogonadism.
Purpose of the Study:
- To review the clinical approach to hypogonadism.
- To discuss traditional and novel physiological induction treatment protocols for hypogonadotropic hypogonadism.
- To highlight the impact of these treatments on long-term fertility success.
Main Methods:
- Literature review of delayed puberty and hypogonadism.
- Analysis of diagnostic and treatment strategies.
- Comparison of traditional hormone replacement with physiological induction therapies.
Main Results:
- Delayed puberty is categorized into hypergonadotropic and hypogonadotropic hypogonadism (permanent or transient).
- CDGP is the leading cause of hypogonadism.
- While testosterone/estrogen are standard, physiological induction therapies (hCG, FSH, GnRH) are emerging for fertility.
Conclusions:
- Effective management of delayed puberty and hypogonadism is crucial.
- Physiological induction therapies offer potential for enhanced fertility in hypogonadotropic hypogonadism.
- Further research is needed to establish clear consensus on optimal induction protocols and their fertility effects.
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