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Terpenes in the management of chronic kidney disease
Piyusha Kulkarni1, Pranali B Yeram1, Amisha Vora2
1Shobhaben Pratapbhai Patel School of Pharmacy & Technology Management, Shri Vile Parle Kelavani Mandal's Narsee Monjee Institute of Management Studies, Mumbai, 400056, India.
Insights
Terpenes, plant compounds, show promise in managing chronic kidney disease (CKD) by targeting inflammation and fibrosis. This review explores their therapeutic potential for renal dysfunction.
Area of Science:
- Phytochemistry and Nephrology
- Pharmacology of Natural Products
Background:
- Chronic kidney disease (CKD) is a progressive, irreversible condition and a leading cause of global mortality.
- Limited therapeutic options exist for CKD management, with diabetes and hypertension as primary risk factors.
- CKD pathology includes glomerulosclerosis, tubular atrophy, and interstitial fibrosis.
Purpose of the Study:
- To review the therapeutic roles and benefits of commonly occurring terpenes in managing CKD.
- To explore how terpenes address the underlying causes and risk factors of CKD.
- To highlight the potential of terpenes in mitigating renal dysfunction.
Main Methods:
- Literature review of evidence-based pharmacological studies on terpenes and CKD.
- Analysis of the mechanisms by which terpenes counteract CKD progression.
- Synthesis of information on the protective attributes of terpenes against renal damage.
Main Results:
- Terpenes exhibit significant therapeutic benefits in managing chronic ailments, including CKD.
- These compounds effectively hinder detrimental pathways like oxidative stress, inflammation, and fibrosis.
- Pharmacological studies support the crucial role of terpenes in preventing and managing CKD.
Conclusions:
- Terpenes represent a promising class of natural compounds for CKD management.
- Their anti-inflammatory, anti-oxidative, and anti-fibrotic properties are beneficial for renal health.
- Further research into terpenes could lead to novel therapeutic strategies for chronic kidney disease.
Abstract:
Chronic kidney disease (CKD) is a chronic and progressive systemic condition that characterizes irreversible alterations in the kidneys' function and structure over an extended period, spanning months to years. CKD is the one of the major causes of mortality worldwide. However, very limited treatment options are available in the market for management of the CKD. Diabetes and hypertension are the key risk factors for the progression of CKD. It is majorly characterised by glomerulosclerosis, tubular atrophy, and interstitial fibrosis. Plants are considered safe and effective in treating various chronic conditions. A diverse group of phytoconstituents, including polyphenols, flavonoids, alkaloids, tannins, saponins, and terpenes, have found significant benefits in managing chronic ailments. Terpenes constitute a diverse group of plant compounds with various therapeutic benefits. Evidence-based pharmacological studies underscore the crucial role played by terpenes in preventing and managing CKD. These substances demonstrate the capacity to hinder detrimental pathways, such as oxidative stress, inflammation and fibrosis, thereby demonstrating benefit in renal dysfunction. This review offers a comprehensive overview of the roles and positive attributes of commonly occurring terpenes in managing the causes and risk factors of CKD and the associated conditions.
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