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Applied physiology: gut microbiota and antimicrobial therapy.

Andrey V Suslov1,2, Alin Panas3, Mikhail Y Sinelnikov4

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Exercise and antibiotics significantly impact the gut microbiota, influencing health and disease. Understanding these interactions is key for developing new therapeutic strategies targeting the gut microbiome.

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Area of Science:

  • Microbiology
  • Human Physiology
  • Pharmacology

Background:

  • The gut microbiota is crucial for human health and disease development.
  • Antibiotics profoundly alter gut microbial composition and function.
  • The gut microbiome is a recognized therapeutic target for various diseases.

Purpose of the Study:

  • To review current literature on gut bacteria's role in cardiovascular, metabolic, and neurodegenerative diseases.
  • To explore the physiological mechanisms by which exercise influences gut microbiota.
  • To elucidate the interplay between exercise and antibiotic therapy on the gut microbiota.

Main Methods:

  • Literature review of publications on gut microbiota, exercise, and antibiotics.
  • Analysis of physiological mechanisms linking physical activity to microbial composition.
  • Examination of common interfaces between exercise and antibacterial therapy in disease pathogenesis.

Main Results:

  • Exercise and antibiotic therapy exert direct effects on the gut microbiota.
  • Specific mechanisms of physical activity's influence on gut microbial composition are identified.
  • The review highlights shared pathways affected by both exercise and antibiotics in disease contexts.

Conclusions:

  • Exercise and antibiotic-induced gut microbiota alterations share physiological links.
  • Understanding these interactions is vital for novel therapeutic interventions.
  • This review provides insights into the gut microbiome's role in health and disease management.