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Possible adrenal involvement in hydroxyurea toxicity defense mechanisms
Archives of Toxicology. Supplement. = Archiv Fur Toxikologie. Supplement
|January 1, 1985
Summary
Hydroxyurea (HYD) causes blood biochemistry changes and lowers white blood cells (WBC) and neutrophils. Adrenalectomy worsens HYD
Area of Science:
- Endocrinology
- Hematology
- Pharmacology
Background:
- Hydroxyurea (HYD) is a medication with known side effects.
- Adrenocortical function is crucial in physiological responses.
- The hematological effects of HYD require further elucidation.
Purpose of the Study:
- To investigate the role of the adrenal cortex in hydroxyurea (HYD)-induced toxicity.
- To explore the protective mechanisms against HYD's hematological effects.
Main Methods:
- Oral administration of hydroxyurea (HYD) at 800 mg/Kg/d for 5 days in rats.
- Adrenalectomy was performed to assess the adrenal gland's role.
- Replacement therapy with corticosterone was used to evaluate its effects.
Main Results:
- Adrenalectomy did not alter HYD-induced blood biochemistry changes but enhanced the decrease in white blood cells (WBC) and neutrophils.
- Corticosterone replacement therapy attenuated or delayed these HYD-induced changes.
- HYD induced blood biochemistry changes resembling adrenocortical hyperfunction.
Conclusions:
- Normally-functioning adrenocortical tissue plays a protective role against HYD's hematological toxicity in rats.
- Drug-induced activation of the hypothalamus-pituitary-adrenal axis appears to counteract HYD toxicity.