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Treatment of Spontaneous Tumors With Algorithmically Controlled Electroporation
IEEE Transactions on Bio-Medical Engineering
|April 29, 2024
Summary
Algorithmically controlled electroporation (ACE) offers a safe and highly effective treatment for equine melanoma, achieving over 93% complete response rates. This innovative method allows for precise temperature control during electroporation, minimizing thermal damage.
Area of Science:
- Veterinary Medicine
- Biomedical Engineering
- Oncology
Background:
- Spontaneous equine melanoma presents a significant clinical challenge.
- Traditional treatments may have limitations in efficacy and safety.
- Electroporation is a promising modality for tumor ablation.
Purpose of the Study:
- To evaluate the safety and efficacy of algorithmically controlled electroporation (ACE) for treating spontaneous equine melanoma.
- To assess the capability of ACE to maintain target temperatures during treatment.
- To determine complete response rates in treated equine melanoma tumors.
Main Methods:
- Development of a custom temperature-sensing coaxial electrode with integrated feedback controls.
- Computational modeling and ex vivo studies to validate temperature control.
- Treatment of 25 equine melanoma tumors using a specific 2000 V ACE protocol.
- Assessment of treatment efficacy 20-50 days post-treatment.
Main Results:
- ACE successfully achieved and maintained target temperatures across diverse tumor types with varying impedance.
- All treatments were completed without adverse events.
- Complete response rates exceeded 93% in all treatment groups.
Conclusions:
- Algorithmically controlled electroporation (ACE) is a safe and effective treatment for spontaneous equine melanoma.
- The temperature control algorithm facilitates rapid, adaptable electroporation delivery.
- ACE minimizes the need for extensive pretreatment planning and real-time adjustments.
