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Plasmablastic myeloma transformation of light-chain multiple myeloma
Nagehan Pakasticali1, Glen L Hortin2, Julie Y Li2
1Department of Pathology and Cell Biology, University of South Florida, Tampa, FL, USA.
Journal of Clinical and Experimental Hematopathology : JCEH
|April 29, 2024
Abstract:
Plasmablastic myeloma (PBM) is an uncommon and aggressive morphologic variant of multiple myeloma (MM). The neoplastic immature cells exhibit diverse morphology, posing a diagnostic challenge. The diagnostic criteria for PBM include the identification of ≥ 2% plasmablasts in the bone marrow aspirate. This case describes the incidental finding of a light-chain multiple myeloma (LCMM) transformed into PBM, a phenomenon not previously reported.

