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Updated: Jun 27, 2025

High-throughput Synthesis of Carbohydrates and Functionalization of Polyanhydride Nanoparticles
Published on: July 6, 2012
HPLC-Based Automated Synthesis and Purification of Carbohydrates
Gustavo A Kashiwagi1, Laura Petrosilli1,2, Samira Escopy1,3
1Department of Chemistry, Saint Louis University, 3501Laclede Ave, St. Louis, Missouri, 63103, USA.
Abstract:
Reported herein is a new HPLC-based automated synthesizer (HPLC-A) capable of a temperature-controlled synthesis and purification of carbohydrates. The developed platform allows to perform various protecting group manipulations as well as the synthesis of O- and N-glycosides. A fully automated synthesis and purification was showcased in application to different carbohydrate derivatives including glycosides, oligosaccharides, glycopeptides, glycolipids, and nucleosides.

