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Related Concept Videos

Tumor Immunotherapy01:27

Tumor Immunotherapy

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Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
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Cancer Vaccines01:30

Cancer Vaccines

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Cancer treatment vaccines are a rapidly evolving field that offers a promising approach to immunotherapy. Unlike traditional vaccines that prevent diseases, cancer treatment vaccines are designed to treat existing cancers by stimulating the immune system to recognize and attack cancer cells.
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...
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Targeted Cancer Therapies02:57

Targeted Cancer Therapies

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The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
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Updated: Jun 27, 2025

Experimental Melanoma Immunotherapy Model Using Tumor Vaccination with a Hematopoietic Cytokine
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CD8+ T cell-based cancer immunotherapy.

Yanxia Chen1, Dingning Yu1,2, Hui Qian1,3

  • 1Jiangsu Key Laboratory of Medical Science and Laboratory Medicine, Department of Laboratory Medicine, School of Medicine, Jiangsu University, Zhenjiang, Jiangsu, 212013, China.

Journal of Translational Medicine
|April 29, 2024
PubMed
Summary

CD8+ T cells are vital for fighting cancer, but tumors can evade their immune attack. This review explores tumor immune evasion and immunotherapy strategies for better cancer treatment.

Keywords:
CAR-TCD8+ T cellCancer therapyCheckpoint inhibitorSolid tumor

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Area of Science:

  • Immunology
  • Oncology
  • Cancer Research

Background:

  • CD8+ T cells are critical immune defenders against pathogens and cancer.
  • Cancer immunotherapy harnesses CD8+ T cells, showing promise for intractable diseases.
  • Tumors can develop resistance mechanisms, challenging CD8+ T cell efficacy.

Purpose of the Study:

  • To review the fundamental biology of CD8+ T cells.
  • To elucidate the mechanisms by which tumors escape immune surveillance.
  • To discuss current and future cancer immunotherapy strategies.

Main Methods:

  • Literature review of CD8+ T cell function.
  • Analysis of tumor immune escape pathways.
  • Synthesis of information on various immunotherapy approaches.

Main Results:

  • CD8+ T cells are essential for anti-tumor immunity.
  • Tumors employ diverse strategies to evade CD8+ T cell-mediated killing.
  • Current immunotherapies offer benefits but also face challenges.

Conclusions:

  • Understanding tumor immune escape is crucial for advancing cancer immunotherapy.
  • Developing novel therapeutic strategies is imperative for overcoming treatment resistance.
  • Future research should focus on enhancing CD8+ T cell function and overcoming tumor evasion.