Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Anatomy of the Intestines01:23

Anatomy of the Intestines

71.8K
Although digestion of proteins, carbohydrates, and lipids may begin in the stomach, it is completed in the intestine. The absorption of nutrients, water, and electrolytes from food and drink also occurs in the intestine. The intestines can be divided into two structurally distinct organs—the small and large intestines.
Small Intestines
The small intestine is an ~7 meter-long tube with an inner diameter of just 2.5 cm. Since most nutrients are absorbed here, the inner lining of the...
71.8K
Drugs for Treatment of Constipation-Predominant IBS01:21

Drugs for Treatment of Constipation-Predominant IBS

160
Pharmacological therapies for IBS-C are designed to alleviate abdominal discomfort and enhance bowel function. In patients with IBS-C, fiber supplements may help soften stools and decrease straining, but may also lead to increased gas production and bloating. Osmotic laxatives like milk of magnesia are frequently used to soften stools and increase stool frequency in IBS-C patients. In addition, two drugs approved for use in severe IBS-C adult cases are linaclotide (Linzess) and lubiprostone...
160

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Interface Excitons in van der Waals Sandwich Heterostructures.

ACS nano·2026
Same author

Helicobacter pylori phages: resource landscape, translational challenges, and engineered antibacterial strategies.

Archives of microbiology·2026
Same author

A novel ZNF263-SMOX-ROS-TRIB3 signaling axis drives Wnt/β-catenin activation and metastatic progression in colorectal cancer.

Apoptosis : an international journal on programmed cell death·2026
Same author

PDIA6-SCD1 Axis Rewires Lipid Metabolism to Drive Gastric Cancer Progression.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)·2026
Same author

CA9 targets ITGB1 to accelerate the progression of colorectal cancer by promoting the neutrophil extracellular traps formation.

Journal of translational medicine·2026
Same author

Dynamic Antibody Responses in Porcine Epidemic Diarrhea Virus-Infected Pigs and Correlation of Prepartum Serum, Oral Swabs, and Rectal Swabs With Postpartum Colostral IgA and IgG in Sows.

Transboundary and emerging diseases·2026

Related Experiment Video

Updated: Jun 27, 2025

Murine Fecal Isolation and Microbiota Transplantation
07:32

Murine Fecal Isolation and Microbiota Transplantation

Published on: May 26, 2023

4.0K

The gut microbiota-constipation connection: Insights from a two sample bidirectional Mendelian randomization study.

Jiajie Zhou1, Xiaoming Yuan1, Yeliu Liu1

  • 1Department of General Surgery, Huai'an First People's Hospital, Nanjing Medical University, Huai'an, Jiangsu Province, China.

Microbial Pathogenesis
|April 30, 2024
PubMed
Summary

Gut microbiota imbalance, specifically lower Coprococcus and higher Bacteroidetes, is linked to constipation risk. This study suggests gut bacteria influence constipation, not the other way around.

More Related Videos

A Method to Define the Effects of Environmental Enrichment on Colon Microbiome Biodiversity in a Mouse Colon Tumor Model
08:14

A Method to Define the Effects of Environmental Enrichment on Colon Microbiome Biodiversity in a Mouse Colon Tumor Model

Published on: February 28, 2018

8.8K
An In Vitro Batch-culture Model to Estimate the Effects of Interventional Regimens on Human Fecal Microbiota
07:15

An In Vitro Batch-culture Model to Estimate the Effects of Interventional Regimens on Human Fecal Microbiota

Published on: July 31, 2019

9.6K

Related Experiment Videos

Last Updated: Jun 27, 2025

Murine Fecal Isolation and Microbiota Transplantation
07:32

Murine Fecal Isolation and Microbiota Transplantation

Published on: May 26, 2023

4.0K
A Method to Define the Effects of Environmental Enrichment on Colon Microbiome Biodiversity in a Mouse Colon Tumor Model
08:14

A Method to Define the Effects of Environmental Enrichment on Colon Microbiome Biodiversity in a Mouse Colon Tumor Model

Published on: February 28, 2018

8.8K
An In Vitro Batch-culture Model to Estimate the Effects of Interventional Regimens on Human Fecal Microbiota
07:15

An In Vitro Batch-culture Model to Estimate the Effects of Interventional Regimens on Human Fecal Microbiota

Published on: July 31, 2019

9.6K

Area of Science:

  • Microbiome research
  • Gastroenterology
  • Genetic epidemiology

Background:

  • Gut microbiota dysbiosis is linked to various health issues, including constipation.
  • Previous research suggests an association between gut microbial imbalance and constipation risk.

Purpose of the Study:

  • To investigate the causal relationship between gut microbiota composition and constipation using bidirectional Mendelian randomization (MR).
  • To identify genetic mechanisms connecting gut microbiota and constipation.

Main Methods:

  • A two-sample bidirectional MR study utilizing gut microbiota data from the MiBioGen consortium and constipation data from the IEU database.
  • Analyses included inverse variance weighting (IVW), MR-Egger, and weighted median methods.
  • Sensitivity analyses employed Cochran's Q test, MR-Egger intercept, MR-PRESSO, and Leave-one-out analysis to ensure result validity.

Main Results:

  • Forward MR analysis indicated a negative correlation between Coprococcus abundance and constipation (OR=0.74, p=0.0001).
  • Forward MR analysis showed a positive correlation between Bacteroidetes abundance and constipation (OR=1.22, p=0.04).
  • No significant influence of constipation on gut microbiota composition was found.

Conclusions:

  • Increased Coprococcus and decreased Bacteroidetes abundance are genetically associated with reduced constipation susceptibility.
  • Findings support the hypothesis that gut microbiota alterations contribute to constipation development.