Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Opioid Analgesics: Synthetic and Semisynthetic Opioids01:15

Opioid Analgesics: Synthetic and Semisynthetic Opioids

287
Synthetic and semisynthetic opioids are pivotal in pain management and tackling opioid addiction. Semisynthetic opioids, including morphinans (morphine derivatives), oxycodone, oxymorphone, hydrocodone, and hydromorphone, have improved pharmacokinetic profiles compared to morphine. Additionally, heroin and 6-MAM (6-Monoacetylmorphine) show better CNS penetration than morphine due to heightened lipid solubility. Hydromorphone, a potent opioid, undergoes hepatic metabolism to form the active...
287
Analgesia and Pain Management01:25

Analgesia and Pain Management

585
Pain is critical to various clinical pathologies, provoking an urgent need for effective management. Pain, whether acute or chronic, is a complex neurochemical process. Its alleviation depends on the type, with nonopioid analgesics effective for mild to moderate pain, such as musculoskeletal or inflammatory pain, while neuropathic pain responds best to anticonvulsants, tricyclic antidepressants, or serotonin/norepinephrine reuptake inhibitors. For severe acute or chronic pain, opioids may be...
585
Opioid Receptors: Overview01:22

Opioid Receptors: Overview

761
Opioid receptors, including the mu (μ, MOR), delta (δ, DOR), and kappa (κ, KOR) types, belong to the rhodopsin family of G protein-coupled receptors. These receptors are located throughout the central and peripheral nervous systems and in non-neuronal tissues such as macrophages and astrocytes. Opioid receptor ligands can be categorized into agonists or antagonists. Highly selective agonists include [d-Ala2, MePhe4, Gly(ol)5]-enkephalin or DAMGO for MOR, [D-Pen2,...
761
Drug Abuse and Addiction: Pharmacological Phenomena01:15

Drug Abuse and Addiction: Pharmacological Phenomena

467
Drug dependence, abuse, and addiction are complex phenomena that can precipitate various abnormal states. Physical dependence refers to a state of pharmacological adaptation to a drug. This adaptation often results in tolerance—a reduced response to the drug after repeated administrations. When the drug use is abruptly stopped, withdrawal symptoms occur due to the body's need to readjust from the pharmacologically induced imbalance. However, tolerance and withdrawal symptoms do not...
467
Opioid Analgesics: Morphine and Other Natural Cogeners01:20

Opioid Analgesics: Morphine and Other Natural Cogeners

242
Opioids are a class of drugs that mimic endogenous opioid peptides and act on opioid receptors, and help in pain relief. These compounds are classified as natural, synthetic, or semi-synthetic. Natural opioids, like morphine, codeine, and thebaine, are derived from the opium poppy plant (Papaver somniferum or Papaver album) and are termed opiates. Synthetic opioids are artificial, while semi-synthetic opioids combine natural and synthetic compounds. Morphine, a prototypical opioid, possesses a...
242

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Nanoparticulate Immunoactive Complex for Local Chemoimmunotherapy: From Murine Models to Pilot Canine Study.

Cancer research communications·2026
Same author

Force-sensing mobile microrobotic grippers for gentle and precise bioassembly of cell spheroids.

APL bioengineering·2026
Same author

Drug Delivery Systems for Resiquimod to Control Myeloid-Derived Suppressor Cells in Cancer Immunotherapy.

Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology·2026
Same author

Subcutaneous tissue structural feature identification using unsupervised machine learning.

Computers in biology and medicine·2026
Same author

Engineering Dynamic Hydrogels via GelMa-AlgMa Hybrids for Enhanced Swelling, Porosity, and Tissue Mimicry.

ACS biomaterials science & engineering·2026
Same author

Phosphatidylserine blockade by dipicolylamine-zinc enhances chemoimmunotherapy of B16F10 melanoma.

Journal of pharmaceutical sciences·2025
Same journal

Endogenous-metabolite-inspired polyamine-oleic acid lipids for safe mRNA delivery and PCSK9 gene editing.

Journal of controlled release : official journal of the Controlled Release Society·2026
Same journal

Tunable rigid spikes on virus-like porous silica enable mechanistically controlled nanovaccine platforms.

Journal of controlled release : official journal of the Controlled Release Society·2026
Same journal

Metabolic regulation-driven nanoparticles for tumor vulnerabilization and enhanced photodynamic therapy.

Journal of controlled release : official journal of the Controlled Release Society·2026
Same journal

New approach methodologies (NAMs) for preclinical and translational evaluation of mRNA-lipid nanoparticle (LNP) therapeutics.

Journal of controlled release : official journal of the Controlled Release Society·2026
Same journal

A cation-free platform based on azocalixarene poly(disulfide)s for direct cytosolic protein delivery.

Journal of controlled release : official journal of the Controlled Release Society·2026
Same journal

Harnessing plant-derived extracellular vesicles for oral delivery: A dual role as natural therapeutics and engineered drug carriers.

Journal of controlled release : official journal of the Controlled Release Society·2026
See all related articles

Related Experiment Video

Updated: Jun 27, 2025

Formulation of Diblock Polymeric Nanoparticles through Nanoprecipitation Technique
06:47

Formulation of Diblock Polymeric Nanoparticles through Nanoprecipitation Technique

Published on: September 20, 2011

37.3K

Multidimensional opioid abuse deterrence using a nanoparticle-polymer hybrid formulation.

Sheryhan F Gad1, Anastasiia Vasiukhina2, Joseph S Keller3

  • 1Department of Industrial and Molecular Pharmaceutics, Purdue University, 575 West Stadium Avenue, West Lafayette, IN 47907, USA; Department of Pharmaceutics, Faculty of Pharmacy, Assiut University, Assiut, Egypt.

Journal of Controlled Release : Official Journal of the Controlled Release Society
|April 30, 2024
PubMed
Summary
This summary is machine-generated.

New abuse-deterrent formulations (ADFs) use tannic acid nanoparticles to block opioid extraction and thermal tampering. This hybrid tablet deters abuse while maintaining therapeutic effects for oral use.

Keywords:
Abuse deterrent formulationDrug abuseGel-forming polymersNanoparticlesOpioid

More Related Videos

Preparation and Characterization of Individual and Multi-drug Loaded Physically Entrapped Polymeric Micelles
07:32

Preparation and Characterization of Individual and Multi-drug Loaded Physically Entrapped Polymeric Micelles

Published on: August 28, 2015

11.3K
Advanced Compositional Analysis of Nanoparticle-polymer Composites Using Direct Fluorescence Imaging
07:41

Advanced Compositional Analysis of Nanoparticle-polymer Composites Using Direct Fluorescence Imaging

Published on: July 19, 2016

7.7K

Related Experiment Videos

Last Updated: Jun 27, 2025

Formulation of Diblock Polymeric Nanoparticles through Nanoprecipitation Technique
06:47

Formulation of Diblock Polymeric Nanoparticles through Nanoprecipitation Technique

Published on: September 20, 2011

37.3K
Preparation and Characterization of Individual and Multi-drug Loaded Physically Entrapped Polymeric Micelles
07:32

Preparation and Characterization of Individual and Multi-drug Loaded Physically Entrapped Polymeric Micelles

Published on: August 28, 2015

11.3K
Advanced Compositional Analysis of Nanoparticle-polymer Composites Using Direct Fluorescence Imaging
07:41

Advanced Compositional Analysis of Nanoparticle-polymer Composites Using Direct Fluorescence Imaging

Published on: July 19, 2016

7.7K

Area of Science:

  • Pharmaceutical Sciences
  • Materials Science
  • Drug Delivery

Background:

  • Prescription opioid misuse is a major public health crisis, leading to overdose deaths.
  • Existing abuse-deterrent formulations (ADFs) aim to prevent tampering but can be circumvented by advanced extraction methods.
  • Developing comprehensive strategies is crucial to combat opioid abuse and diversion.

Purpose of the Study:

  • To develop and evaluate a novel hybrid abuse-deterrent tablet (NP-Tab) using tannic acid nanoparticles (NPs) for enhanced opioid protection.
  • To assess the NP-Tab's resistance to common abuse methods, including solvent extraction, injection, and thermal tampering (crisping).
  • To confirm the NP-Tab's therapeutic efficacy upon oral administration as prescribed.

Main Methods:

  • Fabrication of iron-crosslinked tannic acid NPs encapsulating thebaine (a model opioid).
  • Formulation of NP-Tab tablets incorporating NPs, xanthan gum, and chitosan.
  • Evaluation of NP-Tab performance under simulated abuse conditions: crushing, suspension in solvents, needle passage, and heating.
  • Assessment of drug release in simulated gastric fluid.

Main Results:

  • Crushed NP-Tab formed an instant gel in aqueous solvents, hindering needle extraction.
  • Tannic acid NPs effectively prevented opioid extraction by organic solvents.
  • NPs promoted thermal degradation of the opioid, reducing the reward from crisping.
  • NP-Tab demonstrated rapid thebaine release in simulated gastric fluid, preserving oral therapeutic potential.

Conclusions:

  • The developed NP-Tab offers comprehensive abuse deterrence against extraction, injection, and thermal manipulation.
  • This hybrid formulation effectively complements existing ADF technologies.
  • NP-Tab retains therapeutic efficacy for intended oral administration, addressing a critical need in opioid abuse prevention.