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Development and Maintenance of a Preclinical Patient Derived Tumor Xenograft Model for the Investigation of Novel Anti-Cancer Therapies
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AXL receptor as an emerging molecular target in colorectal cancer

Lucia De Rosa1, Rossella Di Stasi1, Virginia Fusco1

  • 1Istituto di Biostrutture e Bioimmagini, CNR, via P. Castellino, 111 - 80131 Naples, Italy.

Drug Discovery Today
|April 30, 2024
PubMed

Insights

Aberrant AXL receptor tyrosine kinase (AXL) expression drives colorectal cancer (CRC) growth, spread, and drug resistance. Targeting AXL offers promising new therapeutic and diagnostic strategies for CRC management.

Area of Science:

  • Oncology
  • Molecular Biology
  • Cancer Research

Background:

  • Aberrant expression of AXL receptor tyrosine kinase (AXL) is increasingly linked to colorectal cancer (CRC) pathogenesis.
  • AXL signaling contributes to tumor progression, including epithelial-mesenchymal transition (EMT), invasiveness, and metastasis.

Purpose of the Study:

  • To review preclinical evidence associating AXL with colorectal cancer.
  • To highlight the therapeutic and diagnostic potential of targeting AXL in CRC.

Main Methods:

  • Comprehensive literature review of recent preclinical studies on AXL in CRC.
  • Analysis of data linking AXL expression to CRC hallmarks.

Main Results:

  • Preclinical data strongly support AXL's role in promoting CRC growth, EMT, invasion, and metastasis.
  • AXL's involvement in drug resistance mechanisms in CRC is evident.

Conclusions:

  • AXL is a critical mediator in colorectal cancer progression and therapeutic resistance.
  • Targeting AXL presents a promising avenue for developing novel treatments and diagnostic tools for CRC.

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