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NIR-responsive magnesium phosphate cement loaded with simvastatin-nanoparticles with biocompatibility and
Bin Wang1,2, Yanbin Zhao3,4, Yangyang Li3,4
1Department of Orthopedics, Rudong People's Hospital Nantong 226400 Jiangsu China miuguoping@163.com.
RSC Advances
|April 30, 2024
Summary
This study developed a novel magnesium phosphate cement (MPC) using simvastatin-loaded nanocontainers and chitosan. The enhanced MPC demonstrates improved bone formation and mechanical properties for orthopedic applications.
Area of Science:
- Biomaterials Science
- Nanotechnology
- Orthopedic Engineering
Background:
- Magnesium phosphate cement (MPC) has limited osteogenesis, restricting its use in biomedical applications.
- Developing bioactive MPC with enhanced osteogenic performance is crucial for bone regeneration.
- Current MPC formulations require improvements in mechanical strength and biocompatibility.
Purpose of the Study:
- To create an injectable, bioactive magnesium phosphate cement (MPC) with improved osteogenic performance.
- To enhance MPC by incorporating near-infrared (NIR)-responsive nanocontainers loaded with simvastatin (SIM) and modified with polydopamine (PDA).
- To improve mechanical properties and cytocompatibility by introducing chitosan (CHI).
Main Methods:
- Fabrication of simvastatin-loaded mesoporous silica nanoparticles (MSNs) coated with polydopamine (PDA) as nanocontainers (SMP).
- Incorporation of SMP and chitosan (CHI) into magnesium phosphate cement (MPC) to form SMP-CHI MPC.
- Evaluation of physicochemical properties including setting time, pH, injectability, mechanical strength, and degradation behavior.
- Assessment of biocompatibility and osteogenesis through in vitro and in vivo experiments.
Main Results:
- SMP-CHI MPC exhibited a prolonged setting time, near-neutral pH, and excellent injectability.
- Enhanced compressive strength and suppressed rapid degradation were observed in the nanocontainer-incorporated MPC.
- In vitro and in vivo studies confirmed good biocompatibility and significant osteogenic properties of SMP-CHI MPC.
- The multifunctional MPC demonstrated potential for orthopedic applications.
Conclusions:
- The developed multifunctional MPC, reinforced with SMP nanocontainers and CHI, shows promising results for orthopedic applications.
- This approach offers a simple method to produce advanced MPC with enhanced osteogenesis and mechanical properties.
- The study highlights the potential of NIR-responsive nanocontainers and chitosan for improving MPC performance in bone tissue engineering.
