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Related Concept Videos

Antigens Involved in Adaptive Immunity01:26

Antigens Involved in Adaptive Immunity

487
An antigen is any substance the immune system identifies as foreign and potentially harmful to the body, prompting an immune response. Antigens have two functional properties: immunogenicity and reactivity. Immunogenicity is the ability of an antigen to stimulate a specific immune response. At the same time, reactivity describes the antigen's ability to react with the cells and antibodies produced in response to it.
Complete Antigens
Complete antigens possess both immunogenicity and...
487

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Specific antigens in malignancy-associated membranous nephropathy.

Xiaoying Hu1, Guoqin Wang1, Hong Cheng1

  • 1Division of Nephrology, Beijing Anzhen Hospital, Capital Medical University, Beijing, China.

Frontiers in Medicine
|April 30, 2024
PubMed
Summary

Membranous nephropathy (MN) linked to cancer involves specific antigens. This review examines antigen distribution and their role in cancer-associated MN pathogenesis.

Keywords:
NELL-1PLA2RTHSD7Amalignant tumormembranous nephropathy

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Area of Science:

  • Nephrology
  • Oncology
  • Immunology

Background:

  • Membranous nephropathy (MN) is an autoimmune glomerular disease.
  • Malignant tumors are a significant cause of secondary MN, accounting for a notable percentage of cases.
  • Specific antigens like THSD7A and NELL-1 are implicated in MN, but their link to cancer-associated MN requires further clarification.

Purpose of the Study:

  • To review the distribution of MN-specific antigens in patients with cancer-associated MN.
  • To explore the potential role of these antigens in the pathogenesis of malignancy-induced MN.

Main Methods:

  • Literature review of studies investigating MN-specific antigens in patients with co-existing malignant tumors.
  • Analysis of reported antigen expression patterns and their correlation with tumor types.

Main Results:

  • Summarizes findings on the prevalence and types of MN-specific antigens identified in cancer-associated MN.
  • Highlights specific antigens frequently found in patients with underlying malignancies.

Conclusions:

  • Reinforces the association between specific antigens and cancer-related MN.
  • Suggests these antigens may play a crucial role in the development of malignancy-associated membranous nephropathy.