IL-23 past, present, and future: a roadmap to advancing IL-23 science and therapy

Area of Science:

• Immunology
• Biochemistry
• Medical Science

Background:

• Interleukin-23 (IL-23) is a critical cytokine within the IL-12 family.
• It plays a dominant regulatory role in immune-mediated inflammatory diseases (IMIDs).
• Key IMIDs influenced by IL-23 include psoriasis, psoriatic arthritis, and inflammatory bowel disease.

Purpose of the Study:

• To review the fundamental biology of IL-23.
• To examine the role of IL-23 signaling in IMIDs.
• To evaluate the efficacy of IL-23 inhibition as a therapeutic approach for IMIDs.

Main Methods:

• Literature review of IL-23 biology and its role in IMIDs.
• Analysis of existing data on IL-23 signaling pathways.
• Examination of clinical outcomes from anti-IL-23 therapies.

Main Results:

• IL-23 is a central mediator in the pathogenesis of several IMIDs.
• Inhibition of IL-23 has demonstrated therapeutic benefits in treating these conditions.
• Understanding IL-23 biology is crucial for developing targeted therapies.

Conclusions:

• IL-23 is a significant therapeutic target for IMIDs.
• Further research is needed to refine anti-IL-23 therapies and identify patient subgroups.
• Novel molecular ontologies for IL-23-driven diseases could improve patient outcomes.