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Metastasis02:30

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  3. Research Domains
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  7. Oncology And Carcinogenesis
  9. Predictive And Prognostic Markers
  11. Risk Factors Associated With Lymph Node Metastasis In Early-stage Distal Gastric Cancer

Risk factors associated with lymph node metastasis in early-stage distal gastric cancer

Zhiyuan Yu1,2,3, Chen Liang4, Rui Li1,2,3

  • 1School of Medicine, Nankai University, Tianjin, China.

World Journal of Surgery
|April 30, 2024

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Gene Regulation and Targeted Therapy in Gastric Cancer Peritoneal Metastasis: Radiological Findings from Dual Energy CT and PET/CT
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Gene Regulation and Targeted Therapy in Gastric Cancer Peritoneal Metastasis: Radiological Findings from Dual Energy CT and PET/CT

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View abstract on PubMed

Summary
This summary is machine-generated.

Tumor size, location, infiltration depth, and vascular invasion are key predictors of lymph node metastasis in early distal gastric cancer. These factors, along with preoperative albumin and weight loss, inform treatment strategies for T1a tumors.

Area of Science:

  • Oncology
  • Gastroenterology
  • Pathology

Background:

  • Early distal gastric cancer (EDGC) presents a significant clinical challenge.
  • Understanding lymph node metastasis (LNM) risk factors is crucial for effective treatment planning.

Purpose of the Study:

  • To identify independent risk factors for lymph node metastasis (LNM) in early-stage distal gastric cancer.
  • To provide a basis for selecting appropriate treatment protocols for EDGC.

Main Methods:

  • Retrospective observational study of 824 EDGC cases (2010-2020).
  • Univariate and multivariate logistic regression analyses were employed.
  • Clinicopathological features were assessed for association with LNM.

Main Results:

Keywords:
distal gastric cancerearly stagelymph node metastasisrisk factors

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  • 17.0% of cases developed LNM.
  • Independent predictors for LNM included tumor diameter (≥1.75 cm), tumor location, histological classification, infiltration depth, and vascular infiltration.
  • For T1a tumors, preoperative hypoalbuminemia, weight loss, tumor diameter, multiple tumors, histological classification, and vascular infiltration were associated with LNM.

    • Conclusions:

    • Tumor diameter, location, infiltration depth, histological classification, and vascular infiltration are significant predictors of LNM in EDGC.
    • Preoperative hypoalbuminemia, weight loss, tumor diameter/number, histological classification, and vascular infiltration are associated with LNM in T1a tumors.
    • These findings aid in refining treatment strategies for early distal gastric cancer.