Invasive Cardiac Hemodynamics in Apical Hypertrophic Cardiomyopathy
Awais A Malik1, Ushasi Saraswati2, William R Miranda2
1Mayo Clinic, Department of Cardiovascular Medicine Jacksonville FL USA.
Journal of the American Heart Association
|April 30, 2024
Summary
Apical hypertrophic cardiomyopathy often causes elevated left ventricular filling pressures and pulmonary hypertension. Invasive hemodynamics reveal these issues in most patients, with many experiencing reduced cardiac output and right-sided heart failure.
Area of Science:
- Cardiology
- Cardiovascular Research
- Internal Medicine
Background:
- Apical hypertrophic cardiomyopathy (AHC) can cause symptomatic limitations due to diastolic dysfunction, elevated left ventricular filling pressures, and pulmonary hypertension (PH).
- Understanding the invasive cardiac hemodynamics in AHC patients is crucial for managing their condition.
Purpose of the Study:
- To describe the invasive cardiac hemodynamics in a cohort of patients diagnosed with apical hypertrophic cardiomyopathy.
Main Methods:
- Retrospective analysis of 47 patients with AHC who underwent invasive hemodynamic catheterization.
- Data collected included left ventricular filling pressures, pulmonary hypertension, cardiac index, and presence of right-sided heart failure.
Main Results:
- 86% of patients exhibited elevated left ventricular filling pressures at rest or during exercise.
- Pulmonary hypertension was diagnosed in 81% of patients, with 20% of these also having right-sided heart failure.
- Reduced cardiac index was observed in 76% of patients with elevated resting filling pressures.
Conclusions:
- Invasive hemodynamic assessment in AHC patients frequently reveals elevated left ventricular filling pressures and pulmonary hypertension.
- A significant proportion of AHC patients with PH also develop right-sided heart failure.
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