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High-throughput Quantitative Real-time RT-PCR Assay for Determining Expression Profiles of Types I and III Interferon Subtypes
Published on: March 24, 2015
Optimal Treatment Based on Interferon No Longer Makes Clinical Cure of Chronic Hepatitis B Far Away: An
Yujing Li1, Fada Wang1, Jing Zhou1
1Center of Infectious Diseases, West China Hospital, Sichuan University, Chengdu, China.
Insights
Achieving a functional cure for chronic hepatitis B (CHB) is the primary goal. This review explores interferon-based strategies and patient markers for optimizing CHB treatment and cure.
Area of Science:
- Hepatology
- Virology
- Immunology
Background:
- Chronic hepatitis B (CHB) is a significant global health issue.
- Functional cure is the recommended treatment endpoint for CHB.
- Current therapies aim for functional cure, with new trials focusing on this goal.
Purpose of the Study:
- To analyze the concept, benefits, and methods for achieving a functional cure in CHB.
- To review the latest research on interferon-based treatments for CHB functional cure.
- To identify patient populations and biomarkers predictive of successful CHB cure.
Main Methods:
- Review of recent clinical research evidence on CHB functional cure.
- Analysis of interferon-based optimized treatment strategies.
- Examination of virological and serological markers for predicting cure.
Main Results:
- Interferon-based strategies show promise for achieving CHB functional cure.
- Specific patient populations and biomarkers are associated with higher cure rates.
- Challenges remain in the pursuit of a universal CHB cure.
Conclusions:
- Functional cure is an achievable and desirable outcome for CHB management.
- Optimized interferon therapies and biomarker-guided approaches can enhance cure rates.
- Further research is needed to overcome existing obstacles in CHB cure strategies.
Abstract:
Chronic hepatitis B (CHB) remains a major global public health problem. The functional cure is the ideal therapeutic target recommended by the latest guidelines, and pursuing a functional cure has become the key treatment end point of current therapy and for upcoming clinical trials. In this review, based on the latest published clinical research evidence, we analyzed the concept and connotation of clinical cures and elaborated on the benefits of clinical cures in detail. Secondly, we have summarized various potential treatment methods for achieving clinical cures, especially elaborating on the latest research progress of interferon-based optimized treatment strategies in achieving clinical cures. We also analyzed which populations can achieve clinical cures and conducted a detailed analysis of relevant virological and serological markers in screening clinical cure advantage populations and predicting clinical cure achievement. In addition, we also introduced the difficulties that may be encountered in the current pursuit of achieving a clinical cure.
