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Related Concept Videos

Inflammatory Bowel Disease II: Crohn's Disease01:30

Inflammatory Bowel Disease II: Crohn's Disease

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Introduction
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by...
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Inflammatory Bowel Disease I: Ulcerative Colitis01:27

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Introduction
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
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Chronic Bowel Disorders: Introduction01:17

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Chronic bowel diseases are a group of long-term conditions affecting the digestive tract, characterized by inflammation and damage to the gut lining. These conditions primarily include irritable bowel syndrome and inflammatory bowel disease.
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
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Inflammatory Bowel Disease V: Surgical Management01:21

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Surgical interventions for inflammatory bowel disease (IBD), which includes ulcerative colitis and Crohn's disease, are essential in managing symptoms and addressing complications. The selection of surgical procedures is contingent upon the specific conditions and complications that stem from these illnesses.
Here are some common surgical interventions for IBD:
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Irritable Bowel Syndrome I: Introduction01:17

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Irritable Bowel Syndrome (IBS) is characterized by functional disturbances in the gastrointestinal system, presenting a cluster of symptoms without evident structural or biochemical abnormalities. It primarily affects the large intestine and may cause abdominal pain, bloating, excessive gas, diarrhea, constipation, or both.
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Altered...
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Glucocorticoids, a class of anti-inflammatory drugs, are pivotal in treating moderate to severe Crohn's disease by inducing remission. They exhibit their anti-inflammatory action by inhibiting the production of inflammatory cytokines such as tumor necrosis factor (TNF)-α, interleukin (IL)-1, and chemokines like IL-8. In addition, they reduce the expression of inflammatory cell adhesion molecules and inhibit gene transcription of nitric oxide synthase, phospholipase A2, cyclooxygenase-2...
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Investigating Intestinal Inflammation in DSS-induced Model of IBD
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Sacroiliitis in inflammatory bowel disease.

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Inflammatory bowel disease (IBD)-associated sacroiliitis is common but often missed. Early detection via screening tools and imaging review can improve outcomes for this challenging condition.

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Area of Science:

  • Gastroenterology
  • Rheumatology
  • Musculoskeletal Medicine

Background:

  • Sacroiliitis is an underappreciated musculoskeletal complication of inflammatory bowel disease (IBD).
  • Untreated sacroiliitis can lead to joint destruction and chronic pain in IBD patients.
  • IBD affects a younger population, making sacroiliitis a significant contributor to long-term morbidity.

Purpose of the Study:

  • To review current evidence on the epidemiology of IBD-associated sacroiliitis.
  • To discuss prevalence, pathogenesis, diagnostic imaging, and therapeutic challenges.
  • To highlight the underdiagnosis and potential for early detection.

Main Methods:

  • Review of recent scientific literature on IBD-associated sacroiliitis.
  • Analysis of epidemiological data, including prevalence and risk factors.
  • Evaluation of diagnostic modalities and current treatment strategies.

Main Results:

  • Sacroiliitis is increasingly recognized in IBD patients, often detected incidentally on abdominal imaging.
  • A small proportion of IBD patients with sacroiliitis are referred to rheumatologists.
  • Current therapeutic options for IBD-associated sacroiliitis are limited, with potential treatment disparities.

Conclusions:

  • Early detection of IBD-associated sacroiliitis is achievable through clinical screening and imaging review in IBD clinics.
  • Timely rheumatologist referral is crucial for appropriate evaluation and management.
  • Further research is needed to understand pathophysiology and develop targeted therapies.