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Updated: Jun 27, 2025
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Systems Analysis of the Neuroinflammatory and Hemodynamic Response to Traumatic Brain Injury
Published on: May 27, 2022
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Post-traumatic Transient Neurological Dysfunction: A Proposal for Pathophysiology.
Seo-Young Lee1,2,3, Seung Jin Lee4,5, Sam Soo Kim6
1Department of Neurology, Kangwon National University College of Medicine, Chuncheon, Korea.
Journal of Neurotrauma
|April 30, 2024
Summary
Transient neurological dysfunction (TND) can occur after traumatic brain injury (TBI), presenting as aphasia and other focal deficits. These episodes resolve spontaneously, suggesting a link to spreading depolarization in the injured brain.
Area of Science:
- Neurology
- Neurotrauma
- Neuroscience
Background:
- Traumatic brain injuries (TBIs) can lead to unexplained neurological deterioration.
- Post-traumatic transient neurological dysfunction (TND) requires further characterization and understanding of its pathophysiology.
Purpose of the Study:
- To describe the clinical features of TND following acute TBI.
- To investigate the underlying pathophysiology of TND in TBI patients.
Main Methods:
- Retrospective analysis of 14 TBI patients with unexplained focal neurological deterioration.
- Utilized brain imaging (CT, DWI, PWI) and electroencephalography during episodes.
- Collected data over a 48-month period.
Main Results:
- Aphasia was the primary symptom in all 14 patients, developing within 14 days post-trauma.
- Structural imaging showed no interval changes; EEG revealed persistent arrhythmic slowing.
- Perfusion imaging indicated increased cerebral blood flow; symptoms resolved spontaneously within 1 month.
Conclusions:
- Transient neurological dysfunction is a recognized complication of acute TBI.
- TND, though prolonged, resolves spontaneously and may represent spreading depolarization in the injured brain, similar to migraine aura.
Keywords:
cortical spreading depressionmigrainespreading depolarizationtransient neurological dysfunctiontraumatic brain injuryMore Related Videos
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