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    Area of Science:

    • Machine Learning
    • Artificial Intelligence

    Background:

    • Multiple instance learning (MIL) trains models using bags of instances with only bag-level labels.
    • Graph neural networks (GNNs) enhance MIL by capturing intrabag topology.
    • Current GNNs require manual, asynchronous adjustments for graph structures and architectures, which is inefficient.

    Purpose of the Study:

    • To propose a novel reinforced GNN framework for MIL (RGMIL).
    • To address the limitations of manual and asynchronous adjustments in existing GNNs for MIL.
    • To leverage multiagent deep reinforcement learning (MADRL) for automated and synchronized control.

    Main Methods:

    • Developed a reinforced GNN framework for MIL (RGMIL).
    • Pioneered the use of multiagent deep reinforcement learning (MADRL) in MIL tasks.
    • Enabled flexible definition of factors influencing bag graphs and GNNs, with synchronous control.

    Main Results:

    • RGMIL automates adjustments by exploring structure-to-architecture correlations.
    • Experimental results on multiple MIL datasets show RGMIL achieves superior performance.
    • The framework demonstrates excellent explainability.

    Conclusions:

    • RGMIL offers an effective and automated solution for MIL using GNNs and MADRL.
    • The synchronized control of graph structure and GNN architecture improves learning efficiency.
    • The proposed method sets a new benchmark for performance and explainability in MIL.