Tumour budding as a risk factor for lymph node metastases in cutaneous squamous cell carcinoma: a systematic review and meta-analysis
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View abstract on PubMed
Summary
This summary is machine-generated.Tumour budding (TB) is a significant predictor of lymph node metastases in cutaneous squamous cell carcinoma (cSCC). High TB (≥ 5 buds) strongly correlates with increased risk, aiding in stratifying high-risk cSCC patients.
Area Of Science
- Oncology
- Dermatopathology
- Cancer Research
Background
- Current staging systems for cutaneous squamous cell carcinoma (cSCC) have limitations in accurately stratifying high-risk cases.
- Tumour budding (TB) is an emerging prognostic factor in various cancer types.
Purpose Of The Study
- To investigate the prognostic significance of tumour budding (TB) in predicting lymph node metastases (NM) in cSCC.
- To evaluate TB as a potential biomarker for high-risk cSCC.
Main Methods
- A systematic meta-analysis was conducted, including six retrospective studies with 793 cSCC patients.
- Searched PubMed, Web of Science, Embase, and Cochrane databases for studies on TB (5-bud cutoff) and NM in cSCC.
- Odds ratios (OR) were used to assess the association between TB and NM.
Main Results
- A significant association was found between high tumour budding (≥ 5 buds) and lymph node metastases in cSCC.
- The meta-analysis showed a strong odds ratio of 13.29 (95% CI: 5.55-31.86) for NM in patients with high TB.
Conclusions
- Tumour budding is a promising histopathological feature for predicting lymph node metastases in cSCC.
- High TB is a strong risk factor for NM, supporting its use in clinical practice for high-risk cSCC stratification and management.
- Further research is needed to establish standardized reporting guidelines for TB in cSCC.
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