Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Traumatic Brain Injury l: Introduction

Traumatic Brain Injury l: Introduction

DefinitionTraumatic brain injury, or TBI, is a disturbance of normal brain function induced by an external mechanical force, such as a direct blow to the head or a penetrating injury. It can affect both brain structure and function, producing a wide range of clinical outcomes. TBI is a heterogeneous condition, meaning its effects may differ based on the type, location, and severity of the injury.Basis of ClassificationTBI is classified based on severity, injury mechanism, or pathophysiology. In...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

An Ingested Bone Perforating Through the Stomach into the Superior Mesenteric Vein.

The American surgeon·2023

Same author

A Massive Para-Esophageal Hernia: An Unusual Cause of Tension Physiology Leading to Cardiac Arrest.

The American surgeon·2023

Same author

Along with its favorable prognostic role, CLCA2 inhibits growth and metastasis of nasopharyngeal carcinoma cells via inhibition of FAK/ERK signaling.

Journal of experimental & clinical cancer research : CR·2018

Same author

Hemopexin is required for adult neurogenesis in the subventricular zone/olfactory bulb pathway.

Cell death & disease·2018

Same author

Novel Mutations in SCN4A Gene Cause Myotonia Congenita with Scoliosis.

Chinese medical journal·2018

Same author

Plasma Hemopexin ameliorates murine spinal cord injury by switching microglia from the M1 state to the M2 state.

Cell death & disease·2018

Search research articles

Related Experiment Video

Updated: Jul 18, 2026

Investigations on Alterations of Hippocampal Circuit Function Following Mild Traumatic Brain Injury

Investigations on Alterations of Hippocampal Circuit Function Following Mild Traumatic Brain Injury

Published on: November 19, 2012

The Impact of ADP Inhibition on Traumatic Brain Injury Outcomes.

Dana Nielsen¹, Amanda Mathies², Li Cao³

¹General Surgery Residency Program, University of North Dakota, Fargo, ND, USA.

The American Surgeon

|April 30, 2024

Summary

Platelet inhibition by adenosine diphosphate (ADP) does not significantly impact outcomes like mortality or hospital stay after traumatic brain injury (TBI). Further research is needed to clarify ADP

Keywords:

critical care other trauma trauma acute care

More Related Videos

Controlled Cortical Impact Model for Traumatic Brain Injury

Controlled Cortical Impact Model for Traumatic Brain Injury

Published on: August 5, 2014

A Preclinical Controlled Cortical Impact Model for Traumatic Hemorrhage Contusion and Neuroinflammation

A Preclinical Controlled Cortical Impact Model for Traumatic Hemorrhage Contusion and Neuroinflammation

Published on: June 10, 2020

Related Experiment Videos

Last Updated: Jul 18, 2026

Investigations on Alterations of Hippocampal Circuit Function Following Mild Traumatic Brain Injury

Investigations on Alterations of Hippocampal Circuit Function Following Mild Traumatic Brain Injury

Published on: November 19, 2012

Controlled Cortical Impact Model for Traumatic Brain Injury

Controlled Cortical Impact Model for Traumatic Brain Injury

Published on: August 5, 2014

A Preclinical Controlled Cortical Impact Model for Traumatic Hemorrhage Contusion and Neuroinflammation

A Preclinical Controlled Cortical Impact Model for Traumatic Hemorrhage Contusion and Neuroinflammation

Published on: June 10, 2020

Area of Science:

Neurotrauma
Hematology
Critical Care Medicine

Background:

Platelet inhibition, particularly via adenosine diphosphate (ADP) pathways, is linked to traumatic brain injury (TBI) severity and mortality.
The ADP pathway, involving P2Y1 and P2Y12 receptors, is a potential target for managing head injuries.

Purpose of the Study:

To evaluate the impact of adenosine diphosphate (ADP) inhibition on patient outcomes following traumatic brain injury (TBI).
To assess the correlation between varying levels of ADP inhibition and key clinical outcomes using thromboelastography with platelet mapping (TEG-PM).

Main Methods:

A cohort of 98 patients with TBI was analyzed.
Patients were stratified into quartiles based on ADP inhibition levels.
Two groups were compared: ADP inhibition ≤60% versus >60%.

Main Results:

Patients with ADP inhibition <60% were older, had lower Injury Severity Scores (ISS), and higher Glasgow Coma Scale (GCS) scores.
No significant differences were observed in mortality, hospital length of stay, ICU length of stay, or hemorrhage progression between the ADP inhibition groups.
The findings suggest ADP inhibition plays a minimal role in TBI outcomes.

Conclusions:

Adenosine diphosphate (ADP) inhibition does not appear to significantly influence mortality, hospital, or ICU length of stay in TBI patients.
Larger studies and guideline-based assessments are required to fully understand ADP inhibition's role and the necessity of platelet transfusions in TBI management.