Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

lncRNA - Long Non-coding RNAs02:39

lncRNA - Long Non-coding RNAs

8.6K
In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA...
8.6K
Types of RNA01:20

Types of RNA

5.8K
Three main types of RNA are involved in protein synthesis: messenger RNA (mRNA), transfer RNA (tRNA), and ribosomal RNA (rRNA). These RNAs perform diverse functions and can be broadly classified as protein-coding or non-coding RNA. Non-coding RNAs play important roles in regulating gene expression in response to developmental and environmental changes. Non-coding RNAs in prokaryotes can be manipulated to develop more effective antibacterial drugs for human or animal use.
RNA Performs Diverse...
5.8K
Epigenetic Regulation01:37

Epigenetic Regulation

3.0K
Epigenetic changes alter the physical structure of the DNA without changing the genetic sequence and often regulate whether genes are turned on or off. This regulation ensures that each cell produces only proteins necessary for its function. For example, proteins that promote bone growth are not produced in muscle cells. Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
X-chromosome...
3.0K
RNA Polymerase II Accessory Proteins02:36

RNA Polymerase II Accessory Proteins

9.2K
Proteins that regulate transcription can do so either via direct contact with RNA Polymerase or through indirect interactions facilitated by adaptors, mediators, histone-modifying proteins, and nucleosome remodelers. Direct interactions to activate transcription is seen in bacteria as well as in some eukaryotic genes. In these cases, upstream activation sequences are adjacent to the promoters, and the activator proteins interact directly with the transcriptional machinery. For example, in...
9.2K
Chromatin Structure Regulates pre-mRNA Processing02:41

Chromatin Structure Regulates pre-mRNA Processing

7.0K
In eukaryotic cells, nascent mRNA transcripts need to undergo many post-transcriptional modifications to reach the cell cytoplasm and translate into functional proteins. For a long time, transcription and pre-mRNA processing were considered two independent events that occur sequentially in the cell. However, it has now been well established that transcription and pre-mRNA processing are two simultaneous processes that are precisely regulated inside the cell.
The chromatin structure, especially...
7.0K
Riboswitches01:56

Riboswitches

8.1K
Riboswitches are non-coding mRNA domains that regulate the transcription and translation of downstream genes without the help of proteins. Riboswitches bind directly to a metabolite and can form unique stem-loop or hairpin structures in response to the amount of the metabolite present. They have two distinct regions – a metabolite-binding aptamer and an expression platform.
The aptamer has high specificity for a particular metabolite which allows riboswitches to specifically regulate...
8.1K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Global solidarity in genomic surveillance improves early detection of acute respiratory virus threats.

Nature communications·2026
Same author

SUN-domain proteins of the malaria parasite <i>Plasmodium falciparum</i> are essential for proper nuclear division and DNA repair.

mBio·2025
Same author

Cryo-tomography and 3D Electron Diffraction Reveal the Polar Habit and Chiral Structure of the Malaria Pigment Crystal Hemozoin.

ACS central science·2024
Same author

Building genomic capacity for precision health in Africa.

Nature medicine·2024
Same author

A Biotinylated cpFIT-PNA Platform for the Facile Detection of Drug Resistance to Artemisinin in <i>Plasmodium falciparum</i>.

ACS sensors·2024
Same author

Emergence of artemisinin-based combination treatment failure in patients returning from sub-Saharan Africa with P. falciparum malaria.

Journal of travel medicine·2023

Related Experiment Video

Updated: Jun 27, 2025

Methods to Investigate the Regulatory Role of Small RNAs and Ribosomal Occupancy of Plasmodium falciparum
10:22

Methods to Investigate the Regulatory Role of Small RNAs and Ribosomal Occupancy of Plasmodium falciparum

Published on: December 4, 2015

8.9K

Time to switch gears: how long noncoding RNAs function as epigenetic regulators in Apicomplexan parasites.

Vera Mitesser1, Karina Simantov1, Ron Dzikowski1

  • 1Department of Microbiology & Molecular Genetics, The Kuvin Center for the Study of Infectious and Tropical Diseases, IMRIC, The Hebrew University-Hadassah Medical School, Jerusalem 91120, Israel.

Current Opinion in Microbiology
|April 30, 2024
PubMed
Summary

Long noncoding RNAs (lncRNAs) regulate gene expression in Apicomplexan parasites. This review updates knowledge on lncRNA functions and molecular mechanisms in these parasites, aiding future research.

More Related Videos

In Silico Identification and Characterization of circRNAs During Host-Pathogen Interactions
10:27

In Silico Identification and Characterization of circRNAs During Host-Pathogen Interactions

Published on: October 21, 2022

1.5K
Chromatin Isolation by RNA Purification ChIRP
11:09

Chromatin Isolation by RNA Purification ChIRP

Published on: March 25, 2012

86.3K

Related Experiment Videos

Last Updated: Jun 27, 2025

Methods to Investigate the Regulatory Role of Small RNAs and Ribosomal Occupancy of Plasmodium falciparum
10:22

Methods to Investigate the Regulatory Role of Small RNAs and Ribosomal Occupancy of Plasmodium falciparum

Published on: December 4, 2015

8.9K
In Silico Identification and Characterization of circRNAs During Host-Pathogen Interactions
10:27

In Silico Identification and Characterization of circRNAs During Host-Pathogen Interactions

Published on: October 21, 2022

1.5K
Chromatin Isolation by RNA Purification ChIRP
11:09

Chromatin Isolation by RNA Purification ChIRP

Published on: March 25, 2012

86.3K

Area of Science:

  • Molecular Biology
  • Genetics
  • Parasitology

Background:

  • Long noncoding RNAs (lncRNAs) are key gene expression regulators in eukaryotes.
  • A growing number of lncRNAs have been identified in Apicomplexan parasites.
  • These lncRNAs are involved in diverse regulatory roles, including epigenetic modifications and chromatin organization.

Purpose of the Study:

  • To provide an updated overview of lncRNA functions in Apicomplexan parasites.
  • To explore the molecular mechanisms underlying lncRNA-mediated gene regulation in these organisms.
  • To stimulate further research into the biological significance of lncRNAs in parasite biology.

Main Methods:

  • Literature review and synthesis of recent findings on lncRNAs in Apicomplexan parasites.
  • Analysis of proposed molecular mechanisms of lncRNA action.
  • Identification of knowledge gaps and future research directions.

Main Results:

  • lncRNAs in Apicomplexan parasites play roles in marking genes for activation.
  • They contribute to subnuclear compartment formation and organization.
  • lncRNAs influence epigenetic modifications, chromatin structure, and host gene expression.

Conclusions:

  • lncRNAs are versatile regulators of gene expression in Apicomplexan parasites.
  • Understanding their diverse molecular mechanisms is crucial for parasite biology.
  • Further investigation is needed to fully elucidate the roles and potential of lncRNAs in these pathogens.