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Hypothyroidism's effect on stroke limited to specific subtypes: A Mendelian randomization study.

Xinmin Deng1, Wen Chang1, Jingyi Zhu1

  • 1Chengdu University of Traditional Chinese Medicine, China.

Journal of Stroke and Cerebrovascular Diseases : the Official Journal of National Stroke Association
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Summary

Hypothyroidism is linked to an increased risk of specific stroke subtypes, particularly small vessel stroke (SVS). This causal association highlights hypothyroidism as a potential independent risk factor for SVS.

Keywords:
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Area of Science:

  • Endocrinology
  • Neurology
  • Genetics

Background:

  • The relationship between hypothyroidism and stroke risk is debated.
  • Research on hypothyroidism's impact on specific stroke subtypes is limited.

Purpose of the Study:

  • To investigate the causal effect of hypothyroidism on stroke and its subtypes using Mendelian randomization (MR).

Main Methods:

  • Utilized single nucleotide polymorphisms (SNPs) from GWAS as instrumental variables for hypothyroidism.
  • Analyzed summary GWAS data for stroke and subtypes (AS, AIS, LAS, CES, SVS, ICH).
  • Employed univariate and multivariate Mendelian randomization (UVMR, MVMR) for causal effect assessment.

Main Results:

  • Univariate MR indicated hypothyroidism associated with large vessel stroke (LAS) and small vessel stroke (SVS).
  • Multivariate MR, adjusting for risk factors, confirmed a significant causal link between hypothyroidism and SVS.
  • The association between hypothyroidism and LAS was not significant after adjusting for covariates.

Conclusions:

  • Hypothyroidism is causally linked to the risk of LAS and SVS.
  • Hypothyroidism may independently contribute to SVS risk.
  • Vascular risk factors are crucial in the association between hypothyroidism and LAS.