Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Acute Respiratory Failure-V01:29

Acute Respiratory Failure-V

775
The treatment for acute respiratory failure varies based on factors like the underlying cause, overall health, and severity. A collaborative healthcare team is essential for early detection, often through arterial blood gas analysis. Identifying the cause is the primary goal, with treatment strategies adjusted for ventilation/perfusion (V/Q) mismatch, shunting, or diffusion impairment.
Ensure that patients are monitored continuously for their response to therapy, including changes in...
775

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

An automated, digital immunoassay on a microfluidic cartridge for on-demand cytokine profiling.

Microsystems & nanoengineering·2026
Same author

Youth Empowered Self-Care: a direct-to-participant intervention to promote mental well-being.

BMC public health·2026
Same author

Assessing the capability of large language models in answering pediatric critical care board-style questions.

Scientific reports·2026
Same author

Supervised Fine-Tuning of Large Language Models With Chain-of-Thought Reasoning for Pediatric Heart Disease Detection in Unstructured Echocardiogram Reports: Algorithm Development and Validation.

JMIR formative research·2026
Same author

The roadmap for community engagement: co-design and evaluation of a toolkit to strengthen community-academic research partnerships.

Journal of public health (Oxford, England)·2026
Same author

The Authors Reply: Ventilator Liberation after Pediatric Cardiac Surgery: Balancing the Competing Interests of the Lungs and the Heart.

Respiratory care·2026
Same journal

Response to the Letter to the Editor Regarding "Comparative Evaluation of Risk Scores for Predicting Postoperative Pulmonary Complications".

Respiratory care·2026
Same journal

Respiratory Muscle Dysfunction in Stable COPD: A Multimodal Assessment of Diaphragmatic and Cough-Related Impairment.

Respiratory care·2026
Same journal

Flow Asynchronies During Pressure Support Ventilation in Children: A Bench Model Study.

Respiratory care·2026
Same journal

Inspiratory Effort Assessment Using the Occlusion Pressure-Derived Tension-Time Index.

Respiratory care·2026
Same journal

Clinical Usage of High-Flow Nasal Cannula Across Disease Categories and Care Settings: A Nationwide Cohort Study in Japan.

Respiratory care·2026
Same journal

Efficacy of Mechanical Insufflation-Exsufflation Devices as Analyzed in Lung Models: Systematic Review and Network Meta-Analysis of Peak Expiratory Flow Data.

Respiratory care·2026
See all related articles

Related Experiment Video

Updated: May 6, 2026

Invasive Hemodynamic Monitoring of Aortic and Pulmonary Artery Hemodynamics in a Large Animal Model of ARDS
08:12

Invasive Hemodynamic Monitoring of Aortic and Pulmonary Artery Hemodynamics in a Large Animal Model of ARDS

Published on: November 26, 2018

10.1K

A Master Protocol Template for Pediatric ARDS Studies.

Andrew G Miller1, Martha Aq Curley2, Claire Destrampe3

  • 1Division of Pediatric Critical Care Medicine, Duke University Medical Center, Durham, North Carolina; and Respiratory Care Services, Duke University Medical Center, Durham, North Carolina. Andrew.g.miller@duke.edu.

Respiratory Care
|April 30, 2024
PubMed
Summary
This summary is machine-generated.

Developing a master protocol template with common data elements (CDEs) can standardize pediatric acute respiratory distress syndrome (ARDS) trials. This approach aims to overcome barriers and facilitate pooled analysis of clinical trial data in children.

Keywords:
ARDSchildrenclinical trialmechanical ventilationpediatrics

More Related Videos

Surfactant Depletion Combined with Injurious Ventilation Results in a Reproducible Model of the Acute Respiratory Distress Syndrome ARDS
06:22

Surfactant Depletion Combined with Injurious Ventilation Results in a Reproducible Model of the Acute Respiratory Distress Syndrome ARDS

Published on: April 7, 2021

3.4K
Author Spotlight: Simulating Pediatric Cardiac Surgery Using a Neonatal Piglet Model
04:55

Author Spotlight: Simulating Pediatric Cardiac Surgery Using a Neonatal Piglet Model

Published on: May 26, 2023

767

Related Experiment Videos

Last Updated: May 6, 2026

Invasive Hemodynamic Monitoring of Aortic and Pulmonary Artery Hemodynamics in a Large Animal Model of ARDS
08:12

Invasive Hemodynamic Monitoring of Aortic and Pulmonary Artery Hemodynamics in a Large Animal Model of ARDS

Published on: November 26, 2018

10.1K
Surfactant Depletion Combined with Injurious Ventilation Results in a Reproducible Model of the Acute Respiratory Distress Syndrome ARDS
06:22

Surfactant Depletion Combined with Injurious Ventilation Results in a Reproducible Model of the Acute Respiratory Distress Syndrome ARDS

Published on: April 7, 2021

3.4K
Author Spotlight: Simulating Pediatric Cardiac Surgery Using a Neonatal Piglet Model
04:55

Author Spotlight: Simulating Pediatric Cardiac Surgery Using a Neonatal Piglet Model

Published on: May 26, 2023

767

Area of Science:

  • Pediatric Critical Care Medicine
  • Clinical Trial Design
  • Respiratory Medicine

Background:

  • Pediatric acute respiratory distress syndrome (ARDS) is a serious condition with high morbidity and mortality.
  • Clinical trials in pediatric ARDS are limited by design and execution challenges.
  • A master protocol approach can address these barriers and support pediatric ARDS research.

Purpose of the Study:

  • To collaboratively develop a master protocol template for pediatric ARDS clinical trials.
  • To link the master protocol with common data elements (CDEs) for standardization.
  • To facilitate the conduct and analysis of future pediatric ARDS studies.

Main Methods:

  • Conducted a literature search of pediatric ARDS randomized controlled trials (RCTs).
  • Employed a multi-stakeholder, collaborative process to develop a master protocol template.
  • Integrated CDEs and electronic case report forms into the master protocol.

Main Results:

  • Identified 11 small, heterogeneous RCTs in pediatric ARDS.
  • Significant heterogeneity in ARDS definitions, designs, and outcomes was observed.
  • A master protocol template was developed with expert input and linked to CDEs.

Conclusions:

  • Pediatric ARDS trials are often small and heterogeneous, hindering pooled analysis.
  • A standardized master protocol with CDEs can improve comparability and knowledge generation.
  • This approach supports combining and comparing findings from future pediatric ARDS trials.