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Updated: Jun 27, 2025

A Murine Model of Group B Streptococcus Vaginal Colonization
Published on: November 16, 2016
Anti-GBM disease in pregnancy
Abdul Hadi Kafagi1, Anna S Li2,3, David Jayne4
1Manchester University NHS Foundation Trust, Manchester, UK.
None:
We present the case of a pregnant woman in her 20s who presented in her second trimester with severe pulmonary haemorrhage and dialysis-dependent acute kidney failure due to antiglomerular basement membrane (GBM) disease. Responding to therapy, she recovered kidney function and delivered a baby. During her pregnancy, she developed cytomegalovirus viraemia, gestational diabetes and pre-eclampsia. Here, we report the first combined use of cyclophosphamide, rituximab and intensified plasma exchange in anti-GBM disease in pregnancy, allowing minimal exposure to cytotoxic medication, resulting in live birth and dialysis independence.
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