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The Clinical Impact of the Pretreatment Albumin to Fibrinogen Ratio in Esophageal Cancer Patients Who Receive Curative Treatment

The Clinical Impact of the Pretreatment Albumin to Fibrinogen Ratio in Esophageal Cancer Patients Who Receive Curative Treatment

Toru Aoyama ^1,2, Yukio Maezawa ^3,2, Itaru Hashimoto ^4,2, Kentaro Hara ^3,5, Keisuke Kazama ³, Keisuke Komori ³, Aya Kato ³, Kazuki Otani ³, Ayako Tamagawa ³, Haruhiko Cho ^3,2, Junya Morita ³, Shinnosuke Kawahara ³, Mie Tanabe ³, Takashi Oshima ^3,5, Aya Saito ³, Norio Yukawa ³, Yasushi Rino ³

Toru Aoyama ^1,2, Yukio Maezawa ^3,2, Itaru Hashimoto ^4,2

¹Department of Surgery, Yokohama City University, Yokohama, Japan; t-aoyama@lilac.plala.or.jp.
²Department of Gastrointestinal Surgery, Kanagawa Cancer Center, Yokohama, Japan.
³Department of Surgery, Yokohama City University, Yokohama, Japan.
⁴Department of Surgery, Yokohama City University, Yokohama, Japan; itarum1n1@hotmail.com.
⁵Department of Surgery, Tokyo Metropolitan Cancer and Infectious Diseases Center Komagome Hospital, Tokyo, Japan.

⁰Department of Surgery, Yokohama City University, Yokohama, Japan; t-aoyama@lilac.plala.or.jp.

In Vivo (Athens, Greece) +

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April 30, 2024

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View abstract on PubMed

Summary

This summary is machine-generated.

The albumin to fibrinogen ratio (AFR) is a significant prognostic marker for esophageal cancer patients undergoing curative resection. Higher AFR levels correlate with improved overall survival and reduced recurrence risk.

Area Of Science

Oncology
Biochemistry

Background

The albumin to fibrinogen ratio (AFR) is an emerging prognostic indicator in various cancers.
Its role in esophageal cancer prognosis requires further elucidation.

Purpose Of The Study

To investigate the clinical significance of the albumin to fibrinogen ratio (AFR) as a prognostic marker.
To evaluate the impact of AFR on survival outcomes in patients with esophageal cancer who underwent curative resection.

Main Methods

A cohort of 123 esophageal cancer patients treated with curative resection between 2005 and 2020 was analyzed.
Patients were stratified into high-AFR (≥12.3) and low-AFR (<12.3) groups.
Prognostic and clinicopathological parameters were compared between groups, with overall survival (OS) analyzed using log-rank tests and Cox regression.

Main Results

A pretreatment AFR cutoff of 1.23 was identified as significant for OS.
The high-AFR group demonstrated significantly better 3-year (70.8% vs. 46.6%) and 5-year (59.3% vs. 37.4%) OS rates compared to the low-AFR group.
AFR was confirmed as a significant independent prognostic factor for OS in both univariate and multivariate analyses, with a trend towards reduced hematological recurrence in the high-AFR group.

Conclusions

The albumin to fibrinogen ratio (AFR) is a valuable and significant prognostic factor for patients with esophageal cancer.
Elevated AFR levels are associated with improved survival outcomes after curative resection.

Keywords:

Esophageal cancer albumin fibrinogen survival

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