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Related Concept Videos

Tumor Progression02:07

Tumor Progression

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Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
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Metastasis02:30

Metastasis

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Metastasis is the spread of cancer cells from the original site to distant locations in the body. Cancer cells can spread via blood vessels (hematogenous) as well as lymph vessels in the body.
Epithelial-to-Mesenchymal Transition
The epithelial-to-mesenchymal transition or EMT is a developmental process commonly observed in wound healing, embryogenesis, and cancer metastasis. EMT is induced by transforming growth factor-beta (TGF-β) or receptor tyrosine kinase (RTK) ligands, which further...
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  1. Home
  3. Research Domains
  5. Biomedical And Clinical Sciences
  7. Oncology And Carcinogenesis
  9. Predictive And Prognostic Markers
  11. Progression To Lymph Node Metastasis After Spontaneous Regression Of Pulmonary Adenocarcinoma Following Biopsy.
  1. Home
  3. Research Domains
  5. Biomedical And Clinical Sciences
  7. Oncology And Carcinogenesis
  9. Predictive And Prognostic Markers
  11. Progression To Lymph Node Metastasis After Spontaneous Regression Of Pulmonary Adenocarcinoma Following Biopsy.

Related Experiment Video

Initiation of Metastatic Breast Carcinoma by Targeting of the Ductal Epithelium with Adenovirus-Cre: A Novel Transgenic Mouse Model of Breast Cancer
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Initiation of Metastatic Breast Carcinoma by Targeting of the Ductal Epithelium with Adenovirus-Cre: A Novel Transgenic Mouse Model of Breast Cancer

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Progression to Lymph Node Metastasis After Spontaneous Regression of Pulmonary Adenocarcinoma Following Biopsy.

Kyoichi Kaira1, Hisao Imai2, Atsuto Mouri2

  • 1Department of Respiratory Medicine, Comprehensive Cancer Center, International Medical Center, Saitama Medical University, Saitama, Japan kkaira1970@yahoo.co.jp.

In Vivo (Athens, Greece)
|April 30, 2024

View abstract on PubMed

Summary
This summary is machine-generated.

Spontaneous regression (SR) of lung adenocarcinoma is rare. In this case, SR of the primary tumor was followed by metastasis, which was successfully treated with local intervention.

Keywords:
Spontaneous regressionadenocarcinomabiopsylung cancer

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Area of Science:

  • Oncology
  • Immunology

Background:

  • Spontaneous regression (SR) of cancer, the natural disappearance of malignant tumors, is a rare phenomenon.
  • Mechanisms underlying SR are poorly understood, with potential roles for immunological reactions, infections, injuries, and medications.
  • Reported cases of SR in lung cancer are exceptionally limited.

Observation:

  • A case of pulmonary adenocarcinoma with SR is presented.
  • Following complete disappearance of the primary tumor, mediastinal lymph node metastasis exacerbated.
  • This metastasis presented as a single, growing lesion.

Findings:

  • Local treatment, including resection and radiotherapy, proved effective against the metastatic lymph nodes.
  • No recurrence was observed for over three years post-treatment.
lymph node metastasis
  • The case exhibits inconsistent features between the primary lesion and metastatic sites.

    • Implications:

    • This case highlights an unusual presentation of spontaneous regression in lung adenocarcinoma.
    • Physicians should consider local intervention for metastatic exacerbation following primary tumor SR in lung cancer.
    • Further research into SR mechanisms in lung cancer is warranted.