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Measurement of Wall Shear Rate Across the Entire Vascular Wall Using Ultrasound Speckle Decorrelation
Dong Chan Park1, Dae Woo Park1
1Division of Convergence Technology, Research Institute and Hospital, National Cancer Center, Goyang 10408, South Korea.
Insights
Accurate measurement of wall shear rate (WSR) is vital for diagnosing cardiovascular disease. A new speckle decorrelation (SDC) technique with filtering effectively measures WSR noninvasively, promising better patient assessment.
Area of Science:
- Cardiovascular Ultrasound
- Biomedical Engineering
- Medical Imaging
Background:
- Accurate wall shear rate (WSR) measurement is critical for diagnosing cardiovascular disease progression and acute events like aneurysms.
- The speckle decorrelation (SDC) technique measures WSR using 2-D out-of-plane blood flow speed.
- SDC with a 1-D array transducer allows WSR measurement across the entire luminal area.
Purpose of the Study:
- To develop a region-based singular value decomposition (SVD) filtering technique for clutter noise suppression in vascular regions.
- To enable accurate WSR measurement using the SDC technique in clinical settings.
Main Methods:
- Ultrasound simulations were performed to evaluate the technique.
- In-vitro flow experiments were conducted to assess performance.
- An in-vivo human study was performed to validate clinical feasibility.
Main Results:
- The proposed methodology effectively measured WSR across entire vascular walls.
- A conventional 1-D array transducer was utilized with the developed technique.
- The results confirmed the feasibility of the method for clinical application.
Conclusions:
- A noninvasive and accurate SDC-based method for measuring vascular WSR was successfully demonstrated.
- This approach shows significant promise for assessing vascular WSR in healthy and high-risk cardiovascular patients.
- The technique offers a valuable tool for early diagnosis and monitoring of vascular health.
Objective:
The accurate measurement of the wall shear rate (WSR) plays a crucial role in the early diagnosis of cardiovascular disease progression and acute events such as aneurysms and atherosclerotic plaque ruptures. To address this need, the speckle decorrelation (SDC) technique has been used to measure WSR based on the 2-D out-of-plane blood flow speed. This technique is particularly advantageous because it enables the use of a 1-D array transducer to measure WSR over the entire luminal area. This study aims to develop a region-based singular value decomposition (SVD) filtering technique that selectively suppresses clutter noise in the vascular region to measure WSR using SDC.
Method:
Ultrasound simulations, in-vitro flow experiments, and an in-vivo human study were conducted to evaluate the feasibility of this method's clinical application.
Results:
The results demonstrated that WSR can be effectively measured across entire vascular walls using a conventional 1-D array transducer along with the proposed methodology.
Conclusion:
This study successfully demonstrates a noninvasive and accurate SDC-based method for measuring vital vascular WSR. This approach holds significant promise for assessing vascular WSR in both healthy individuals and high-risk cardiovascular disease patients.
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