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GPCRs Regulate Adenylyl Cylase Activity

GPCRs Regulate Adenylyl Cylase Activity

Some GPCRs transmit signals through adenylyl cyclase (AC), a transmembrane enzyme. AC helps synthesize second messenger cyclic adenosine monophosphate (cAMP). AC catalyzes cyclization reaction and converts ATP to cAMP by releasing a pyrophosphate. The pyrophosphate is further hydrolyzed to phosphate by the enzyme pyrophosphatase, which drives cAMP synthesis to completion. However, cAMP is rapidly degraded to 5′ AMP by the enzymes phosphodiesterase (PDE), preventing overstimulation of...

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Related Experiment Video

Updated: Jun 27, 2025

Rare Event Detection Using Error-corrected DNA and RNA Sequencing

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Published on: August 3, 2018

Author Correction: GPCR molecular dynamics forecasting using recurrent neural networks

Juan Manuel López-Correa¹, Caroline König^1,2, Alfredo Vellido^3,4

¹Universitat Politècnica de Catalunya, Barcelona, Spain.

Scientific Reports

|April 30, 2024

Summary

No abstract available in PubMed .

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