Prognostic and Predictive Significance of Ki67 in Primary Non-metastatic or Recurrent Acral Melanoma: Evidence from a Multicenter Retrospective Study

Chengcai Liang ^1,2, Dandan Li ^1,3, Yin Liang ^1,2

⁰State Key Laboratory of Oncology in South China, Guangdong Provincial Clinical Research Center for Cancer, Collaborative Innovation Center for Cancer Medicine, Sun Yat-sen University Cancer Center, Guangzhou, China.

Annals of Surgical Oncology +

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April 30, 2024

View abstract on PubMed

Summary

High Ki67 levels in acral melanoma (AM) correlate with worse outcomes and adverse features. Routine Ki67 evaluation is recommended for improved prognostic prediction and risk stratification in AM patients.

Area Of Science

Oncology
Dermatology
Pathology

Background

Acral melanoma (AM) is a distinct subtype of cutaneous melanoma.
Prognostic markers are crucial for managing AM patients.

Purpose Of The Study

To investigate the prognostic significance of Ki67 expression in primary and recurrent acral melanoma.
To assess the association of Ki67 with clinicopathological features and patient survival.

Main Methods

Retrospective analysis of Ki67 values in primary (pKi67) and recurrent (rKi67) lesions from 481 and 97 AM patients, respectively.
Correlation of pKi67 and rKi67 with clinicopathological variables and survival outcomes (overall survival, recurrence-free survival, survival after recurrence).

Main Results

High pKi67 was associated with ulceration, advanced tumor stage (pT4), lymph node metastasis, and recurrence.
Elevated pKi67 and rKi67 levels significantly correlated with poorer 5-year overall survival, recurrence-free survival, and survival after recurrence.
Multivariate analysis confirmed Ki67 as an independent prognostic factor for survival outcomes in both primary and recurrent AM.

Conclusions

Ki67 expression is a significant independent prognostic marker in acral melanoma.
High Ki67 values indicate adverse pathological and prognostic features.
Routine Ki67 assessment is recommended for enhanced risk stratification and prognostic prediction in AM.

Keywords:

Acral melanoma (AM) Ki67 Overall survival (OS) Recurrence-free survival (RFS) Survival after recurrence (SAR)

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