Related Experiment Video

Updated: Jun 27, 2025

Using RNA-sequencing to Detect Novel Splice Variants Related to Drug Resistance in In Vitro Cancer Models
09:58

Using RNA-sequencing to Detect Novel Splice Variants Related to Drug Resistance in In Vitro Cancer Models

Published on: December 9, 2016

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Research Progress of Long Non-Coding RNA in Tumor Drug Resistance: A New Paradigm

Jing Zhang1, Le Wu1, Chenchen Wang2

  • 1Laboratory of Tissue Engineering, Faculty of Life Science, Northwest University, Xi'an, Shaanxi, People's Republic of China.

Drug Design, Development and Therapy
|May 1, 2024
PubMed

Insights

Long non-coding RNAs (lncRNAs) contribute to cancer drug resistance by affecting biological processes. Understanding lncRNA mechanisms is key to overcoming resistance and improving targeted cancer therapies.

Area of Science:

  • Oncology
  • Molecular Biology
  • Genomics

Background:

  • Chemotherapy is a primary cancer treatment, but drug resistance remains a significant challenge.
  • Mechanisms of cancer drug resistance are complex and not fully understood.
  • Long non-coding RNAs (lncRNAs) are newly identified genomic elements involved in various cellular processes.

Purpose of the Study:

  • To review the role of lncRNAs in mediating resistance to targeted cancer drugs.
  • To elucidate the mechanisms by which lncRNAs contribute to drug resistance.
  • To provide a theoretical basis for developing novel targeted therapies against drug-resistant tumors.

Main Methods:

  • This review synthesizes current research on lncRNAs and cancer drug resistance.
  • Focuses on studies investigating lncRNA expression and function in high-mortality tumors.
  • Examines genetic and epigenetic factors influencing drug response.

Main Results:

  • Abnormal expression of lncRNAs is implicated as a factor in cancer drug resistance.
  • lncRNAs influence critical biological processes, including transcription, epigenetics, and cell cycle regulation.
  • Genetic variations and polymorphisms in metabolic genes also impact patient treatment response.

Conclusions:

  • lncRNAs represent a significant area of study for understanding and overcoming cancer drug resistance.
  • Targeting lncRNAs holds promise for developing more effective cancer treatments.
  • Further research into lncRNA mechanisms is essential for advancing targeted cancer therapy.
Keywords:
chemotherapydrug resistanceimmune escapelncRNAtumor

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