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Updated: Jun 27, 2025
10:37
Deep Proteome Profiling by Isobaric Labeling, Extensive Liquid Chromatography, Mass Spectrometry, and Software-assisted Quantification
Published on: November 15, 2017
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Proteomics appending a complementary dimension to precision oncotherapy.
Zhaokai Zhou1,2, Ruiqi Zhang1, Aoyang Zhou1
1Department of Interventional Radiology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan 450052, China.
Summary
High-throughput proteomics enables precise protein quantification for analyzing molecular signatures. This review explores proteomics technologies and data integration for advancing precision medicine and tumor treatment.
Area of Science:
- Biochemistry
- Molecular Biology
- Proteomics
Background:
- High-throughput proteomic profiling allows precise quantification of multiple proteins across specimens.
- Advances in data analysis facilitate the integration and consolidation of proteomics data.
- Proteomics aids in understanding molecular mechanisms and identifying biomarkers for precision medicine.
Purpose of the Study:
- To review current proteomics technologies.
- To discuss progress and methods for proteomics data integration.
- To explore the integration of proteomics into precision medicine and clinical settings.
Main Methods:
- Review of high-throughput proteomic profiling technologies.
- Analysis of data integration methods for proteomics.
- Discussion of applications in precision medicine and clinical settings.
Main Results:
- Proteomics technologies offer comprehensive molecular signature analysis.
- Integrated proteomics data can identify key molecular mechanisms and biomarkers.
- The potential for merging proteomics in precision medicine is significant.
Conclusions:
- Proteomics is a powerful tool for molecular analysis in research and clinical settings.
- Data integration is crucial for leveraging proteomics in precision medicine.
- Further integration of proteomics will enhance precision treatment of tumors.
Keywords:
Data integrationMolecular typingPrecision oncotherapyProtein networkProteomicsProteomics analysis technologyMore Related Videos
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