Related Experiment Video
Updated: Jul 20, 2026
07:29
Studying Pancreatic Cancer Stem Cell Characteristics for Developing New Treatment Strategies
Published on: June 20, 2015
19.6K
A comprehensive review on phytochemicals in the treatment and prevention of pancreatic cancer: Focusing on their
Md Kamrul Hasan Arnab1, Md Rabiul Islam2, Mohammad Saydur Rahman1
1Department of Pharmacy Jagannath University Dhaka Bangladesh.
Health Science Reports
|May 1, 2024
Summary
Natural compounds show promise for pancreatic cancer treatment, offering alternatives to low-success therapies. Further clinical research is recommended to validate these promising natural anticancer agents.
Area of Science:
- Oncology
- Natural Product Chemistry
- Cancer Therapeutics
Background:
- Pancreatic cancer has a poor prognosis with limited treatment options.
- Current therapies like chemotherapy and radiotherapy have low success rates.
- There is a critical need for novel and effective pancreatic cancer treatments.
Purpose of the Study:
- To explore novel therapeutic strategies for pancreatic cancer.
- To review the potential of natural compounds as anticancer agents.
- To identify alternative treatments for pancreatic cancer.
Main Methods:
- Comprehensive literature review of pancreatic cancer pathophysiology and treatments.
- Analysis of data from Scopus, PubMed, and Google Scholar.
- Identification and evaluation of natural compounds with anticancer properties.
Main Results:
- Natural compounds like cannabinoids, curcumin, quercetin, resveratrol, and triptolide exhibit anticancer potential.
- These phytochemicals target key cancer pathways including apoptosis, autophagy, and cell growth.
- They also influence processes like oxidative stress and epithelial-mesenchymal transition.
Conclusions:
- Surgery remains the primary treatment, but is often not feasible due to late diagnosis.
- Natural compounds and herbal medicines represent promising complementary therapies for pancreatic cancer.
- Large-scale, standardized clinical research is essential to validate natural compounds for pancreatic cancer treatment.
Related Concept Videos
02:59Cancer Prevention
Several factors can increase the risk of cancer in an individual. About 50% of cancer cases can be prevented by adopting a healthy lifestyle, regular exercise, eating healthy, and following a modest cancer prevention diet. Epidemiological studies have consistently shown that populations with vegetable and fruit-rich diets have reduced the incidence of cancer. On the other hand, populations who have a diet rich in animal fat, red meat, junk food, or high calories are predisposed to cancer.
Some...
Some...
02:57Targeted Cancer Therapies
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...
There are several types of targeted therapies against specific...
01:24Chronic Pancreatitis I: Introduction
The pancreas, an elongated and flat gland situated behind the stomach, serves a vital function in digesting food and managing blood sugar levels.
Pancreatitis is the inflammation of the pancreas, which occurs when the immune system becomes active and causes swelling, pain, and disruptions in organ function. Pancreatitis can manifest as either an acute or chronic condition.
Acute pancreatitis arises suddenly and lasts for a brief duration, while chronic pancreatitis is a long-term affliction...
Pancreatitis is the inflammation of the pancreas, which occurs when the immune system becomes active and causes swelling, pain, and disruptions in organ function. Pancreatitis can manifest as either an acute or chronic condition.
Acute pancreatitis arises suddenly and lasts for a brief duration, while chronic pancreatitis is a long-term affliction...
01:29Chronic Pancreatitis II: Collaborative Care
The management of chronic pancreatitis is multifaceted, involving a comprehensive approach that includes thorough assessment, diagnostic testing, and a variety of management strategies.
Assessment:
Assessment:
01:25Chronic Pancreatitis I: Introduction
Chronic pancreatitis is a long-standing, relapsing inflammation of the pancreas, characterized by irreversible damage to the gland. It results in progressive destruction of the pancreatic parenchyma, fibrosis, and eventual loss of both exocrine and endocrine function. The disease may evolve gradually after multiple episodes of acute pancreatitis or develop independently.EtiologyChronic pancreatitis can arise from a variety of causes:Alcohol use is the leading cause, accounting for 70–80% of...
01:21Chronic Pancreatitis II: Pathophysiology
Chronic pancreatitis is a progressive and irreversible inflammation of the pancreas, most often caused by long-term alcohol abuse, but it can also be related to ductal obstruction, smoking, or genetic factors.Chronic pancreatitis occurs when the pancreas is repeatedly exposed to harmful agents like alcohol, smoking, ductal obstruction, or genetic predisposition. These factors lead to the release of toxic metabolites and inflammatory cytokines, sustaining chronic inflammation in the pancreatic...