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  7. Oncology And Carcinogenesis
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  11. Evaluation Of Cleaved Caspase-3 And Ki-67 Index On Diagnostic Biopsy In Response To Neoadjuvant Chemotherapy In The Context Of Post-treatment Tumour Ypt Stage, Ypn Stage, Grade, And Molecular Subtype

Evaluation of cleaved caspase-3 and Ki-67 index on diagnostic biopsy in response to neoadjuvant chemotherapy in the context of post-treatment tumour ypT stage, ypN stage, grade, and molecular subtype

Vasil Nanev1, Hristo Milev2, Desislava Dimitrova2

  • 1Medical University of Pleven, Pleven, Bulgaria.

Przeglad Menopauzalny = Menopause Review
|May 1, 2024

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View abstract on PubMed

Summary
This summary is machine-generated.

Assessing cleaved caspase-3 and Ki-67 on diagnostic biopsies helps predict neoadjuvant chemotherapy response in breast cancer patients. These markers correlate with post-treatment prognostic factors, aiding in treatment decisions.

Area of Science:

  • Oncology
  • Pathology

Background:

  • Breast carcinoma is a complex disease with varied clinical presentations.
  • Understanding factors influencing treatment response is crucial for patient management.

Purpose of the Study:

  • To evaluate the relationship between cleaved caspase-3 and Ki-67 index on diagnostic biopsies and response to neoadjuvant chemotherapy.
  • To assess these markers in the context of molecular subtype, post-treatment tumor characteristics, and grade.

Main Methods:

  • Retrospective analysis of 110 breast cancer patients.
  • Evaluation of Ki-67 and cleaved caspase-3 expression on diagnostic biopsies.
  • Correlation with tumor grade, molecular subtype, and post-neoadjuvant treatment categories (ypT, ypN).

Main Results:

Keywords:
Ki-67breast cancercleaved caspase-3diagnostic biopsy of breast cancer

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  • Ki-67 levels significantly correlated with tumor grade, molecular subtype, and post-neoadjuvant tumor size/invasion.
  • Cleaved caspase-3 expression showed a significant relationship with post-neoadjuvant therapy response according to Sataloff classification.
  • No significant difference in Ki-67 was found between pathological complete response and other response groups.

Conclusions:

  • Cleaved caspase-3 and Ki-67 index on diagnostic biopsy are valuable predictors of post-neoadjuvant treatment prognostic factors.
  • These markers can aid in predicting treatment response and guiding further patient management in breast cancer.
neoadjuvant chemotherapy
prognostic biomarkers