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Aspirin interruption before neurosurgical interventions: A controversial problem
Alexander Kulikov1, Anton Konovalov2, Pier Paolo Pugnaloni3
1Department of Anesthesiology, Burdenko National Medical Research Center of Neurosurgery, Moscow 125047, Russia.
Insights
Chronic aspirin use may not require interruption before neurosurgery, challenging current guidelines. This review examines aspirin
Area of Science:
- Neurosurgery
- Cardiology
- Pharmacology
Background:
- Aspirin is common for preventing ischemic events.
- Chronic aspirin use may increase surgical bleeding risk.
- Neurosurgical guidelines recommend aspirin cessation 7 days prior, lacking strong evidence.
Purpose of the Study:
- To review evidence challenging the necessity of aspirin interruption before neurosurgery.
- To discuss aspirin effect monitoring and its clinical implications.
- To summarize bleeding risk data for aspirin users undergoing neurosurgery.
Main Methods:
- Narrative review of existing literature.
- Analysis of clinical data on aspirin and bleeding in neurosurgical patients.
- Evaluation of aspirin effect monitoring techniques.
Main Results:
- Evidence suggests aspirin interruption may not be necessary for all neurosurgical patients.
- Aspirin effect monitoring offers options for managing perioperative risk.
- Bleeding risk varies across different neurosurgical procedures (brain tumors, cerebrovascular, spinal).
Conclusions:
- Current guidelines for aspirin interruption before neurosurgery may be overly cautious.
- Personalized management based on aspirin effect monitoring and procedure type is warranted.
- Further research is needed to refine recommendations for aspirin use in neurosurgery.
Abstract:
Aspirin is widely used for primary or secondary prevention of ischemic events. At the same time, chronic aspirin consumption can affect blood clot formation during surgical intervention and increase intraoperative blood loss. This is especially important for high-risk surgery, including neurosurgery. Current European Society of Cardiology guidelines recommend aspirin interruption for at least 7 d before neurosurgical intervention, but this suggestion is not supported by clinical evidence. This narrative review presents evidence that challenges the necessity for aspirin interruption in neurosurgical patients, describes options for aspirin effect monitoring and the clinical implication of these methods, and summarizes current clinical data on bleeding risk associated with chronic aspirin therapy in neurosurgical patients, including brain tumor surgery, cerebrovascular procedures, and spinal surgery.
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