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Odontogenic keratocysts: A retrospective histopathological study
Aadithya Basavaraj Urs1, Priya Kumar1, Shivani Singh2
1Department of Oral Pathology and Microbiology, Maulana Azad Institute of Dental Sciences, New Delhi, India.
National Journal of Maxillofacial Surgery
|May 1, 2024
Summary
Odontogenic keratocysts (OKCs) are aggressive, recurrent cysts. Histological features like basal cell budding and suprabasal splitting are linked to recurrence, aiding in better surgical outcomes.
Area of Science:
- Oral pathology
- Surgical oncology
- Dermatology
Background:
- Odontogenic keratocyst (OKC) is characterized by aggressive behavior and high recurrence rates.
- Factors influencing OKC recurrence include surgical techniques and specific histopathological features.
- Understanding the true nature of OKC is crucial for effective management.
Purpose of the Study:
- To analyze clinical, radiographic, and histopathological data of Odontogenic Keratocysts (OKCs).
- To identify specific histological features associated with OKC recurrence.
- To enhance comprehension of OKC biology for improved treatment outcomes.
Main Methods:
- Assessment of 58 Odontogenic Keratocyst (OKC) lesions, including four associated with nevoid basal cell carcinoma syndrome (NBCCS).
- Evaluation of radiographic characteristics and histopathological features of the epithelium and capsule.
- Analysis of clinical data including patient demographics and lesion location.
Main Results:
- The study included 58 OKC lesions, with 72% in males and 28% in females.
- Common radiographic findings included unilocular radiolucency (65%) in the mandibular ramus (43%).
- Histopathological analysis revealed true parakeratinization (95%), cuboidal basal cell morphology (41.3%), reversal of polarity (60%), basal budding, rete pegs, and epithelial separation (94.9%).
Conclusions:
- Histopathological features such as basal cell budding, suprabasal mitotic activity, and epithelial separation are strongly associated with Odontogenic Keratocyst (OKC) recurrence.
- Emerging genetic and molecular research offers new insights into OKC biology.
- Improved post-surgical results are anticipated with a better understanding of these factors.
